抗人类免疫缺陷病毒蓝藻蛋白-N研究进展  

Advancement in research of cyanovirin-N, a HIV-inactivating protein

作　　者：李奇渊[1] 章军[1] 

机构地区：[1]厦门大学生命科学学院,福建厦门361005

出　　处：《中国新药与临床杂志》2003年第6期371-375,共5页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：蓝藻抗病毒蛋白 N (cyanovirin N ,CV N )是一种从椭孢念珠藻 (Nostocelliposporum )中分离出的抗病毒活性蛋白 ,能够有效地抑制多个亚型的人类免疫缺陷病毒Ⅰ (HIV Ⅰ ) ,Ⅱ (HIV Ⅱ )以及猴免疫缺陷病毒 (SIV )。CV N的上述特性使它可能成为艾滋病 (AIDS)的潜在高效治疗药物。大量研究证明 ,CV N与包膜糖蛋白 12 0 (GP12 0 )具有高度亲和性并能够阻断由包膜蛋白介导的细胞融合过程从而阻止病毒的扩散。CVCyanovirin N(CV N), a 11KD anti HIV polypeptide, was originally isolated from blue green algae Nostoc elliposporum . The most special character of CV N is that it can markedly suppress the activity of several substrains of HIV Ⅰ ,HIV Ⅱ and SIVs. Such suppression of HIV makes CV N an extraordinary valuable potential medicine for AIDS treatment. Researchers have proved that CV N has a specific affinity to GP120 and can subsequently interfere the cell fusion mediated by it, which causes the further infection of HIV among cells. CV N defines a new strategy of AIDS treatment through natural viruscidous peptide.

关 键 词：蓝藻抗病毒蛋白-N 艾滋病 人类免疫缺陷病毒 包膜糖蛋白120 

分 类 号：R978.7[医药卫生—药品] R512.91[医药卫生—药学]