不同剂量加味保元汤对束缚应激小鼠非特异性免疫功能的影响  

Effect of the Modified Baoyuan Tang on Macrophage Phagocytosid in Restrained Stress Mice

作　　者：孙莉[1] 韩耀辉[1] 

机构地区：[1]大连经济技术开发区,大连大学医学院,生理教研室,116622

出　　处：《中国心理卫生杂志》2003年第6期401-402,396,共3页Chinese Mental Health Journal

摘　　要：目的 :研究不同剂量加味保元汤对束缚应激小鼠非特异性免疫功能的影响。方法 :80只小鼠随机等分为加味保元汤 5g/kg体重、 10g/kg体重、15g/kg体重和应激组 ,用巨噬细胞体内吞噬法 ,测其吞噬率及吞噬指数。结果 :吞噬指数 :10g/kg体重组明显高于 15g/kg体重组 (P <0 0 5 ) ,10g/kg体重组与 5g/kg体重组比较虽P >0 0 5 ,但均值高于 5g/kg体重组 ;吞噬率 :10g/kg体重组最高。结论 :10g/kg体重剂量加味保元汤对束缚应激小鼠非特异性免疫功能保护作用效果最佳。Objective: To investigate the effect of the modified Baoyuan Tang (BYT) with different doses on macrophage phagocytosis in restrained stress mice Method: 80 mice were randomly divided into 4 groups receiving different dose of BYT (stress only, 5g/kg, 10g/kg, 15g/kg) Using the intracellular phagocytosis in vivo to assess the phagocytosis ratio (Ph R) and phagocytosis index (Ph I) Result: The Ph R was highest in 10g/kg group The average of Ph I was also highest in 10g/kg group, but the difference between 10g/kg group and 5g/kg group had no statistic significance Conclusion:BTY 10g/kg has the best protective effect for decreased phagocytosis caused by restrained stress in mice

关 键 词：保元汤 中药 束缚应激 巨噬细胞 动物实验 非特异性免疫功能 

分 类 号：R285.5[医药卫生—中药学]