止眩颗粒剂的提取工艺研究  

Study on extraction technology of Zhixuan Granula

作　　者：文红梅[1] 李伟[1] 彭国平[1] 朱荃[1] 张正行[2] 

机构地区：[1]南京中医药大学,江苏南京210029 [2]中国药科大学,江苏南京210009

出　　处：《中草药》2003年第6期508-510,共3页Chinese Traditional and Herbal Drugs

基　　金：国家中医药管理局青年基金项目 (97Y0 14 )

摘　　要：目的　优选止眩颗粒剂的制备工艺。方法　以 2 3-乙酰泽泻醇 B、白术内酯 提取率和固形物得率为指标 ,采用正交试验法对止眩颗粒剂的提取工艺进行优选 ,并以小鼠镇静作用的药效学验证。结果　优化工艺为 :泽泻、白术先以 12倍量 70 %乙醇分 2次回流提取 ,每次 2 h;再以 14倍量水分 2次煎煮 ,每次 2 h。提取物对小鼠有明显的镇静作用。结论　该工艺合理 ,有效成分提取效率高。Object To optimize the preparation procedure for Zhixuan Granula (ZXG). Methods The optimum extracting conditions of ZXG were selected by orthogonal test with the active components: 23-acetate alisol B, atractylenolide I, and dried extract as the index, it mice sedation of ZXG was clarified by pharmacodynamics. Results The optimum preparation procedure was as follows: Rhizoma Alismatis and Rhizoma Atractylodis Macrocephalae were extracted with alcohol first, adding 12-fold 70% alcohol by refluxing, extracting twice, 2 h once, then extracted with water, adding 14-fold water, extracting twice, 2 h once. The extract showed the obvious effect on sedation of mice. Conclusion The optimum preparation procedure is reliable, with higher extracting ratio of the active components.

关 键 词：止眩颗粒剂 提取工艺 研究 23—乙酰泽泻醇B 白术内酯I 提取率 正交试验 镇静作用 

分 类 号：R286[医药卫生—中药学] R284.2[医药卫生—中医学]