醒脑静注射液的体外抗多形核白细胞与血管内皮细胞粘附的效果  

Effect of Xingnaojing Injection on PMN Adhering to BMVEC in Vitro

作　　者：李志刚[1] 刘松青[1] 王章阳[1] 

机构地区：[1]第三军医大学西南医院药学部,重庆市400038

出　　处：《中国药房》2003年第6期333-334,共2页China Pharmacy

摘　　要：目的 :研究醒脑静注射液的抗粘附效果及机理。方法 :利用兔多形核白细胞(PMN)悬液与兔脑微血管内皮细胞(BMVEC)共育 ,观察醒脑静注射液对内毒素所导致的PMN -BMVEC粘附及血小板活化因子 (PAF)和一氧化氮 (NO)水平变化的影响。结果 :醒脑静可以明显降低PMN -BMVEC粘附率以及培养基中PAF、NO的水平。结论 :醒脑静可以抑制PMN -BMVEC的粘附及部分介质的分泌 。OBJECTIVE:To investigate the anti-adherence effect and its mechanism of Xingnaojing(XNJ)injecˉtion.METHODS:In mixed culture of rabbit’s PMN and brain microvascular endothelial cell(BMVEC),the effects of XNJ on LPS-induced PMN-BMVEC adhesion and the changes of PAF and NO levels were observed.RESULTS:XNJ could obviously decrease the PMN-BMVEC adhesion rate and the levels of NO and PAF in culture medium.CONCLUSION:XNJ can inhibit adhesion of PMN to BMVEC and release of some inflammatory media.The decrease of some inflammatory media may related to the reduction of adhesion.

关 键 词：醒脑静注射液 多形核白细胞 血管内皮细胞 粘附 兔 血小板活化因子 一氧化氮 

分 类 号：R285.5[医药卫生—中药学]