丹芝舒心胶囊的制备及临床观察  

Preparation and Clinical Observation of Danzhisuxing Capsule

作　　者：宋炳生[1] 倪江洪[1] 苏全胜[1] 李汉宝[1] 谢虞升[1] 陈安兰[1] 

机构地区：[1]南京军区南京总医院,南京市210002

出　　处：《中国药房》2003年第6期339-341,共3页China Pharmacy

摘　　要：目的 :研究丹芝舒心胶囊的制备方法及质控标准 ,并观察其临床疗效。方法 :对处方中的丹参、元胡、冰片进行薄层色谱鉴别 ,测定醇溶性浸出物的含量 ,并进行动物急性毒性试验和临床观察。结果 :层析分离清晰 ,空白无干扰 ,重现性好。动物试验LD50>12 08g生药/kg。临床总有效率为86 80%。结论 :组方合理 ,工艺可行 ,质控方法可靠 ,无毒性 ;OBJECTIVE:To prepare Danzhisuxin capsule,establish the standard of quality control and to observe its cliniˉcal effect.METHODS:Dadix salviae miltiorrhizae,Rhizoma corydalis and Borneolum sytheticum in Danzhisuxin capsule were identified by TLC.The amount of alcohol extract was measured.Animal acute toxic test was performed and clinical effects were observed.RESULTS:Checking with TLC was simple and rapid.This method was feasible and had a good repeatability.In anˉimal test,LD 50 >12.08g herbs/kg.The overall effective rate for coronary heart disease was86.8%.CONCLUSION:Danzhisuxin capsule is appropriate in formulation and feasible in preparation technique.The method of quality control is reliˉable.No toxic reactions were found and the clinical effect was satisfactory.

关 键 词：丹芝舒心胶囊 制备 临床观察 临床疗效 动物急性毒性试验 冠心病 心绞痛 

分 类 号：R286.23[医药卫生—中药学]