影响丙戊酸钠血药浓度波动的因素及应对措施  

Factors Influencing the Serum Concentration of Valproic Acid and Countermeasures

作　　者：周金玉[1] 王奎兴[1] 孙增先[1] 

机构地区：[1]江苏省连云港市第一人民医院临床药理室,连云港市222002

出　　处：《中国药房》2003年第6期353-354,共2页China Pharmacy

摘　　要：目的 :探讨影响丙戊酸钠血药浓度波动的因素 ,提高丙戊酸钠血药浓度检测的有效性及可利用性。方法 :归纳总结影响丙戊酸钠血药浓度波动的因素 ,提出应对措施。结果 :服药时间、采血时间、监测时机、剂型及制剂质量、患者依从性、合并用药、患者生理和病理指标等均为影响丙戊酸钠血药浓度波动的因素。结论 :在癫痫患者长期服药治疗过程中 ,医师、患者、药师应互相沟通 ,建立监测档案 ,密切注意影响丙戊酸钠血药浓度波动的因素 ,以确保患者用药的安全。OBJECTIVE:To observe the factors that influence the fluctuation of serum concentrations of valproic acid and to improve the effectiveness and usefulness of monitoring the serum concentration.METHODS:The factors that influence the serum concentration of valproic acid were summed up and the countermeasures were put forward.RESULTS:These influencing factors included the drug administration time;the blood sampling time;the right moment for monitoring;the dosage forms and quality of drug;the obedience of patient;combining use of drugs and the physiological and pathological conditions of paˉtients.CONCLUSION:When epileptic patients receive long-term medical treatment,the doctor,the patient and the pharmaˉcist should communicate mutually,establish the relevant data,pay attention to those factors and ensure the patients safe and effective in use of drug.

关 键 词：丙戊酸钠 血药浓度 影响因素 癫痫 不良反应 服药时间 采血时间 

分 类 号：R971.6[医药卫生—药品]