氯沙坦联用倍他乐克治疗充血性心力衰竭的疗效观察  

Effects of losartan plus betaloc on congestive heart failure

作　　者：窦敬权[1] 秦延莉[2] 

机构地区：[1]广东医学院附属医院急救中心,广东湛江524001 [2]中日友好医院心内科,北京100013

出　　处：《广东医学院学报》2002年第6期426-427,共2页Journal of Guangdong Medical College

摘　　要：目的 :观察氯沙坦 (商品名 :科素亚 )联用倍他乐克治疗充血性心力衰竭 (CHF)的疗效。方法 :CHF60例按就诊顺序随机分为A、B组 ,A组分别给予氯沙坦 2 5～ 10 0 mg,1次 /天 ,倍他乐克始剂量为 6.2 5 mg,1次 /天 ,以后缓慢递增 ;B组给予氯沙坦 2 5～ 10 0 mg,1次 /天。结果 :两组的心率、心胸比、血压、射血分数 ,左室收缩末期内径组间比较差异有非常显著性 (P<0 .0 1)。结论 :氯沙坦联用倍他乐克治疗可使 CHF患者心功能显著改善 。Objective:To observe the effects of losartan and betaloc on congestive heart failure(CHF).Methods:Sixty patients with CHF were randomly divided into group A( n =30) and B( n =30).Patients in group A took losartan(25～100 mg once daily) and betaloc[6.25 mg(NYHA Ⅲ IV) or 12.5 mg once daily(NYHA Ⅱ)];while those in group B only received losartan(25～100 mg once daily).The follow up time was 8 weeks.Results:There were significant differences between two groups in heart rate,heart chest ratio,blood pressure,ejection fraction and left ventricular end systolic diameter( P< 0.01).The drugs were well tolerated.Conclusion:Combined administration of losartan and betaloc could profoundly improve the cardiac function in patients with CHF.

关 键 词：氨沙坦 倍他乐克 联合治疗 充血性心力衰竭 疗效观察 

分 类 号：R541.61[医药卫生—心血管疾病]