α干扰素对尖锐湿疣患者皮损表皮细胞凋亡和增殖的影响  

Effects of Interferon-α on cell Proliferation and Apoptosis in Patients with Condyloma Injury of Skin

作　　者：雷水生[1] 张端莲[2] 万克英[1] 马利尔 王杨 

机构地区：[1]咸宁医学院皮肤性病学教研室,湖北咸宁437100 [2]武汉大学医学院组织胚胎学教研室,湖北武汉430071 [3]咸宁市中心医院皮肤科,湖北咸宁437100

出　　处：《医学新知》2003年第2期81-82,88,共3页New Medicine

基　　金：湖北省科技攻关课题项目批号:2 0 0 2AA30 5B0 6

摘　　要：目的　研究α -干扰素对尖锐湿疣患者皮损表皮细胞凋亡和增殖的影响。方法　采用免疫组织化学方法和末端脱氧核苷酸转移酶介导的末端标记技术 (TUNEL法 ) ,检测 40例患者皮损表皮细胞凋亡和增殖状态 ,并对细胞凋亡和PCNA阳性细胞进行计数。结果　α 干扰素治疗后PCNA阳性细胞数明显减少而凋亡细胞数增加 ,与治疗前比较差异均有显著性 (P <0 .0 5)。结论　INFObjective To study the effects of interferon α on cell proliferation and apoptosis in patients with condyloma injury of skin. Method The proliferation of endothial cell and necrosis condition of hemangioma were detected with immunohis to chemistry method and TdT Mediated duTP Nick End Labeling (TENUL) in 40 patients,and the PCNA positive and necrosis cells were counted.Result After treated with interferon α,the number of PCNA cells reduced obviously,and the number of necrasis cells increased obviously. A significant difference was noted(P<0.05).Conclusion INF α could promote apoptosis and restrain proliferation.

关 键 词：Α-干扰素 尖锐湿疣 皮损 表皮细胞凋亡 表皮细胞增殖 免疫组织化学 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]