重组人生长激素在慢性心力衰竭患者的临床应用  

A clinical application of recombinant human growth hormone to chronic heart failure

作　　者：李彦红[1] 王凤芝[1] 韩丽瑄[1] 郝林娃[1] 马京炬[2] 

机构地区：[1]山西医科大学第二医院心内科,030001 [2]山西省临汾市人民医院心内科

出　　处：《中国药物与临床》2003年第3期207-209,共3页Chinese Remedies & Clinics

摘　　要：目的　了解重组人生长激素 (rhGH)对扩张性心肌病 (DCM )和缺血性心肌病 (ICM )患者心功能的影响和安全性。方法　 30例缺血性心肌病和扩张性心肌病所致慢性心力衰竭患者 (ICM :治疗组 1 1例 ,对照组 1 1例 ;DCM :治疗组 4例 ,对照组 4例 ) ,两组患者均行常规抗心力衰竭治疗 ,同时治疗组隔日腹部皮下注射rhGH 4U ,共 1个月。治疗前后分别进行心脏彩色超声、血流动力学及血清胰岛素生长因子 (IGF) Ⅰ、血浆血管紧张素(Ang) Ⅱ的测定。结果　治疗组的左室收缩功能较对照组明显改善 (P <0 0 5) ,舒张功能两组之间差异无显著性 ;血清IGF Ⅰ治疗组较对照组明显升高 ;血浆Ang Ⅱ治疗组较对照组降低明显 ,但治疗后两组比较差异无显著性 (P>0 0 5)。结论　①rhGH可明显改善ICM和DCM患者的左室收缩功能。Objective To assess the safety and the effect of recombinant human growth hormone (rhGH) on cardiac function in the treatment of patients with dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM).Methods Thirty patients with DCM and ICM were studied at baseline and after a one month therapy either with rhGH ( n =15,4 U QOD,i.h.) or with routine therapy ( n =15).Cardiac function was assessed by echocardiography and cardiodynamics.Results rhGH improved left ventricular (LV) systolic function ( P <0 05),but no difference in diastolic function between rhGH therapy group and placebo group ( P >0 05).Conclusion rhGH given to patients with DCM and ICM is safe;rhGH could improve LV systolic function.

关 键 词：重组人生长激素 慢性心力衰竭 临床应用 扩张性心肌病 缺血性心肌病 治疗 

分 类 号：R541.6[医药卫生—心血管疾病]