高乌甲素对炎症性疼痛的镇痛作用  

Analgesic effect of lappaconitine on inflammatory pain

作　　者：刘铭佩[1] 

机构地区：[1]兰州医学院第二附属医院药剂科,730030

出　　处：《中国药物与临床》2003年第3期244-245,共2页Chinese Remedies & Clinics

摘　　要：目的　研究高乌甲素对急、慢性炎症的镇痛作用。方法　采用大鼠甲醛溶液致炎 ,鹿角菜胶致炎及佐剂性关节炎三种炎症性疼痛模型进行实验。结果　高乌甲素 8、1 6mg/kg灌胃对急性 (甲醛溶液 ,鹿角菜胶致炎 )及慢性 (佐剂性关节炎 )的炎症性疼痛有明显镇痛作用 ,峰值在给药后 0 5～ 1h ,持续 2h以上。结论　高乌甲素对急。Objective To study the analgesic effect of lappaconitine (LAP).Methods The analgesic effect of LAP was investigated with three inflammatory pain models including formaldehyde test,carrageenan induced inflammation and adjuvant induced arthritis in Wistar rats.Results The data obtained suggested that LAP (8,16 mg/kg,ig) possess significant analgesic effect both on acute (formaldehyde test and carrageenan induced inflammation) and chronic (adjuvant induced arthritis) inflammatory pain.The peak time was 0 5～1 h after administration.The analgesic action of LAP lasted about two hours.Conclusion LAP has a significant analgesic effect on acute and chronic inflammatory pain.

关 键 词：高乌甲素 炎症性疼痛 镇痛作用 鹿角菜胶 

分 类 号：R285[医药卫生—中药学]