新生儿败血症的病原菌及耐药性分析  

Pathogens Causing Newborn′ Septicemia and Their Antibiotic Resistance

作　　者：杨锦红[1] 李向阳[1] 张楚南[1] 

机构地区：[1]温州医学院育英儿童医院,浙江温州325027

出　　处：《中华医院感染学杂志》2003年第6期572-574,共3页Chinese Journal of Nosocomiology

摘　　要：目的　了解近 10年新生儿败血症的病原菌分布及其耐药状况。方法　对 1991～ 2 0 0 0年我院新生儿血培养结果进行分析和总结。结果　 85 9例阳性标本中表皮葡萄球菌和金黄色葡萄球菌分别占 32 .9%和 16 .1% ,对多种抗生素耐药 ,苯唑西林的耐药率分别为 6 7.6 %、70 .5 % ,对万古霉素 10 0 %敏感 ;革兰阴性菌中大肠埃希菌占首位 ,其次为肺炎克雷伯菌、肠杆菌属、假单胞菌属 ;抗菌活性较好的药物是亚胺培南、阿米卡星、环丙沙星。结论　葡萄球菌是新生儿败血症的主要病原菌 ;新生儿败血症的病原菌具多重耐药性 ,应积极防治。OBJECTIVE To learn the distribution of pathogens causing newborn′septicemia and their antibiotic resistance. METHODS The results in blood culture of newborns in our hospital from 1991 to 2000 were analyzed. RESULTS Among 859 positive samples of blood culture, positive ratio of Staphylococcus epidermidis and S. aureus were 32.9% and 16.1%, respectively. Furthermore, they were multiresistant. The ratio of meticillin-resistant S.epidermidis and S.aureus was 67.6% and 70.5%, respectively, but all were sensitive to vancomycin. Among Gram-negative bacteria, Escherichia coli was in the first place, the second one was Klebsiella pneumoniae, the others were Enterobacter, Pseudomonas spp. The better antibiotics for them were imipenem, amikacin, and ciprofloxacin. CONCLUSIONS Staphylococcus spp is one of the main pathogens causing newborn′ septicemia. These pathogens were multiresistant, and some measures against them should be taken.

关 键 词：新生儿败血症 病原菌 耐药性 

分 类 号：R515.3[医药卫生—内科学]