产超广谱β-内酰胺酶菌在老年患者中的感染  

ESBLs-producing Gram-negative Bacteria in Senile Patients: A Clinical Investigation

作　　者：卢小军[1] 吴升[1] 张丽君[1] 周春[1] 

机构地区：[1]解放军117医院,浙江杭州310013

出　　处：《中华医院感染学杂志》2003年第6期586-587,共2页Chinese Journal of Nosocomiology

摘　　要：目的　了解产超广谱 β 内酰胺酶菌在老年患者中的感染情况 ,指导临床合理使用抗菌药物。方法　对1997年 1月～ 2 0 0 1年 10月 5 4 1份老年患者的各类标本中分离出的细菌进行分析 ,采用双纸片协同试验检测产超广谱 β 内酰胺酶菌株 ,纸片扩散法测定产超广谱 β 内酰胺酶菌株对 17种抗菌药物的敏感性。结果　产超广谱β 内酰胺酶菌株的总检出率 19.6 % ;产超广谱 β 内酰胺酶菌株对亚胺培南和头孢哌酮 /舒巴坦的敏感性达 10 0 %。结论　产超广谱β 内酰胺酶菌在老年患者中的感染率较高 ,临床宜选用亚胺培南和头孢哌酮 /舒巴坦治疗。OBJECTIVE To study the infection condition of extended-spectrum β-lactamases(ESBLs) -producing Gram-negative bacilli in senile patients for reasonable use of antibiotics in clinic. METHODS The double-disk synergy test was performed to detect ESBLs-producing strains and 17 antibiotics were determined by the antimicrobial disk diffusion susceptibility tests in specimen collected from 741 senile patients. RESULTS The total rate of ESBLs-producing Gram-negative bacilli in senile patients was 28.7%. All strains of ESBLs were susceptible to imipenem and cefoperazone/ sulbactam(100%). CONCLUSIONS Imipenem and cefoperazone/ sulbactam were better for the infection caused by ESBLs-producing Gram-negative bacilli in senile patients.

关 键 词：Β-内酰胺酶类 抗药性 微生物 

分 类 号：R378.2[医药卫生—病原生物学]