不同剂量甲硫咪唑治疗Graves病的比较  

Methimazole in the Treatment of Graves' Disease —Small-Dose Monotherapy or Daily Multiple Large-Dose Therapy?

作　　者：赵家胜[1] 贺铭[1] 谷磊[1] 雷涛[1] 张秀珍[1] 

机构地区：[1]同济大学附属同济医院内分泌科,上海200065

出　　处：《同济大学学报（医学版）》2003年第3期224-226,共3页Journal of Tongji University(Medical Science)

摘　　要：目的　比较每日一次小剂量与每日多次大剂量甲硫咪唑治疗Graves病的有效性和安全性。方法　患者随机分为 2组 ,单剂量组每日一次口服甲硫咪唑 15mg ,大剂量组每日一次 3 0mg ,分 3次口服 ,然后比较两组的缓解率、药物副反应发生率和停药后的复发率。结果　两组缓解率和复发率相似 ,但单剂量组的副反发生率显著低于大剂量组。结论　每日 15mg单剂量口服甲硫咪唑治疗Graves病疗效与多次大剂量相似 。Objective To compare the efficacy and safety of small-dose methimazole monotherapy with that of daily large-dose multiple therapy in the treatment of Graves' disease.Methods 50 patients with Graves' disease were divided randomly into two groups: group A and group B.in group A took 15 mg methimazole once daily and 24 patients in group B took a total of 30 mg,10 mg 3 times a day.To evaluate the remission rate of Graves' disease, the prevalence of adverse drug reactions after 3 months and the relapse rate of thyrotoxicosis in two groups.Results The remission rate and the relapse rate in two goups were similar,but the prevanlence of adverse drug reactions in group A was remarkedly less than that in group B.Conclusion Treatment of Graves' disease with a small single daily dose of methimazole is superior to daily multiple large-dose therapy.

关 键 词：甲亢 GRAVES病 甲硫咪唑 剂量 疗效比较 

分 类 号：R581.1[医药卫生—内分泌]