黄芪川芎对实验性糖尿病大鼠肾脏形态学的影响  

Effect of Radix Astragali and Ligusticum Chancing Hort on Renal Histology in Experimental Diabetic Rats

作　　者：刘宝义[1] 李英[2] 

机构地区：[1]河北省唐山市人民医院,唐山063001 [2]河北医科大学第三医院,石家庄050051

出　　处：《中国中西医结合肾病杂志》2003年第6期323-325,共3页Chinese Journal of Integrated Traditional and Western Nephrology

摘　　要：目的 :探讨黄芪与川芎对实验性糖尿病 (DM )大鼠肾脏形态学的影响。方法 :SD系大鼠 4 5只 ,链脲佐菌素 (STZ)腹腔内注射制成DM模型 ,分为DM治疗 (DT)组、DM组和正常对照 (NC)组。DT组采用黄芪 7.0g/kg和川芎 1.2 g/kg体重 ,水煎后灌喂 ,每日 1次 ,共 6周。于 2周、4周、6周时分别取肾脏行光镜和电镜检查。 结果 :DT组可明显减轻肾小球肥大、系膜细胞、系膜基质增生及肾小球基底膜 (GBM )增厚。结论 :黄芪川芎可以减轻DM大鼠肾脏形态学损害 。Objective:To study the effect of radix astragali(Bge) and ligusticum chuanxiong Hort(Hort) on renal histology in experimental diabetic rats.Methods:Forty-five SD rats was randomly divided into three groups: diabetes treated group(DT),diabetes mellitus groups(DM) and normal control groups(NC).The diabetes model was established by intraperitoneal injction of STZ. 7.0 g/kg of Bge and 1.2 g/kg of Hort were given to rats in DT group by gavage once a day for 6 weeks. The kidneys were processed for morphological examination with light and electronic microscopes at 2,4,6 weeks.Results:Compared with DM group, Bge and Hort treatment significantly suppressed glomerular enlargement, mesangial cell and matrix proliferation and GBM thickening. Conclusion:Bge and Hort treatment can attenuate renal histological damage in diabetic rats.

关 键 词：黄芪 川芎 实验性糖尿病大鼠 肾脏 形态学 

分 类 号：R285.5[医药卫生—中药学]