SARS冠状病毒对血液系统的影响及可能的机制(英文)  被引量:39

The Effect of SARS Coronavirus on Blood System:Its Clinical Findings and the Pathophysiologic Hypothesis

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作  者:杨默[1] 韩锦伦[1] 李桂霞[1] 霍泰辉[1] 李志光[1] 

机构地区:[1]香港中文大学儿科学系

出  处:《中国实验血液学杂志》2003年第3期217-221,共5页Journal of Experimental Hematology

摘  要:20 0 2年 11月在广东发现首例严重急性呼吸综合征 (俗称“非典型性肺炎”)病例。 2 0 0 3年 2月世界卫生组织 (WHO)在越南河内正式确认此疾病为新的人类传染病 ,并命名为严重急性呼吸综合征 (severeacuterespiratorysyndrome ,SARS)。 2 0 0 3年 3月在香港发现其病原体为新的冠状病毒 (coronavirus) ,称之为SARS冠状病毒 (SARS CoV)。SARS患者常常出现异常的血液学改变 ,包括淋巴细胞减少 (在成人为 6 8% - 90 % ;在儿童为 10 0 % ,n =10 ) ,血小板减少 (成人 2 0 % - 4 5 % ,儿童 5 0 % ) ,和白细胞减少 (成人 2 0 % - 34% ,儿童 70 % )。同时在部份患者D 二聚体水平可见升高。初步的研究表明SARS冠状病毒可侵犯造血细胞 ,但作用机制尚不清楚。我们推测其病理生理过程可能包括 :(1)通过CD13或CD6 6a受体 ,SARS病毒直接侵入造血细胞或感染骨髓基质细胞等 ,加重细胞凋亡 ,引致造血抑制 ;(2 )通过生成自身抗体或免疫复合物等免疫介导造成细胞损害。肺部损害也可部分解释血小板减少。肺部可能是成熟巨核细胞释出血小板的器官之一。SARS病人有广泛肺泡损害 ,包括充血、水肿、透明膜形成和肺纤维化 ,使肺部有效毛细血管床减少 ,从而血小板生成减少。同时 ,炎症损伤使肺部血小板聚集、血栓形成 ,也引致血小板?Severe acute respiratory syndrome (SARS) has recently recognized as a new human infectious disease. A novel coronavirus was identified as the causative agent of SARS. This report summarizes the hematological findings in SARS patients and proposes a hypothesis for the pathophysiology of SARS coronavirus related abnormal hematopoiesis. Hematological changes in patients with SARS were common and included lymphopenia (68%-90% of adults; 100% of children, n=10), thrombocytopenia (20%-45% of adults, 50% of children), and leukopenia (20%-34% of adults, 70% of children). The possible mechanisms of this coronavirus on blood system may include (1) directly infect blood cells and bone marrow stromal cells via CD13 or CD66a; and/or (2) induce auto antibodies and immune complexes to damage these cells. In addition, lung damage in SARS patients may also play a role on inducing thrombocytopenia by (1) increasing the consumption of platelets/megakaryocytes; and/or (2) reducing the production of platelets in the lungs. Since the most common hematological changes in SARS patients were lymphopenia and immunodeficiency. We postulate that hematopoietic growth factors such as G CSF, by mobilizing endogenous blood stem cells and endogenous cytokines, could become a hematological treatment for SARS patients, which may enhance the immune system against these virus.

关 键 词:SARS SARS冠状病毒 淋巴细胞减少症 血小板减少症 白细胞减少症 

分 类 号:R511[医药卫生—内科学]

 

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