CD4^+CD25^+调控T细胞及其在移植耐受中的作用  

CD4^+CD25^+ Regulatory T Cells and Their Function in Maintaining Transplantation Tolerance

作　　者：伏瑞祥[1] 吴德沛[1] 

机构地区：[1]苏州大学附属第一医院,江苏省血液研究所苏州215006

出　　处：《中国实验血液学杂志》2003年第3期321-324,共4页Journal of Experimental Hematology

摘　　要：CD4 + CD2 5 + 调控T细胞是一群表型和功能特异的T细胞亚群 ,能抑制CD4 + CD2 5 -和CD8+ T细胞的活化和增殖 ,以及IL 2和IFN γ的产生 ,在移植免疫耐受中发挥着重要的作用 ,其免疫调控机理仍不明确。CD4 +CD2 5 + 在体外能有效地被分离、活化和扩增 ,并能保持其免疫调控能力 ,其活化后的免疫抑制功能是抗原非特异性的。体外活化和扩增的CD4 + CD2 5 +This article reviews that as a functionally and phenotypically distict immunoregulatory T cell subpopulation, CD4 +CD25 + regulatory T cells can suppress the activation and proliferation of CD4 +CD25 - T cells and CD8 + T cells and the production of IL 2 and IFN γ. These regulatory cells play an important role in allograft tolerance, although the mechanisms are not completely understood to date. CD4 +CD25 + regulatory T cells can be isolated, activated and expanded in vitro without loss of their immunoregulatory function. The suppressive function of activated CD4 +CD25 + cells is antigen non specific. Ex vivo activated and expanded regulatory T cells have a perspective for practical use.

关 键 词：CD4^+CD25^+调控T细胞 T细胞 移植耐受 

分 类 号：R392.4[医药卫生—免疫学] R457.7[医药卫生—基础医学]