食管癌中ICE、Fas、FasL的表达及其意义  

Expression and significance of the ICE, Fas and FasL protein in the esophageal carcinoma

作　　者：张红[1] 晏梅[1] 文小岗[1] 高冬玲[1] 牛韵韵[1] 张云汉[1] 

机构地区：[1]郑州大学第一附属医院病理科

出　　处：《中国康复理论与实践》2003年第6期344-345,355,共3页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的了解食管癌组织中的促凋亡状况及其与抗肿瘤免疫的关系。方法采用免疫组化 L SAB法对 4 6例食管癌手术切除标本中的白细胞介素 1β转化酶 (IL- 1β converting enzyme,ICE)、Fas、Fas L 蛋白进行标记 ,并对其中 13例进行 Td T介导d UTP缺口末端标记。结果 ICE、Fas、Fas L蛋白在癌巢中的阳性率分别为 78.2 6 %、6 0 .87%和 4 7.83% ,ICE蛋白的表达程度与癌组织学分级有相关性。结论癌组织表达 Fas、Fas L,可能参与癌细胞的免疫逃避 ;ICE的表达与癌组织分化有一定关系。ObjectiveTo study the relationship between the antitumor immunoreaction and the cell apoptosis in esophageal carcinoma.MethodsThe IL-1β converting enzyme, Fas and FasL protein were labeled by LSAB immunohistochemistric method in 46 cases of esophageal carcinoma, of which 13 cases were labeled by TdT mediated dUTP nick end labeling (TUNEL).ResultsThe positive rates of ICE, Fas and FasL proteins in the cancer nests were 78.26%, 60.87% and 47.83%. The expression of ICE protein was related to the histological grading of the cancer.Conclusions The expression of Fas, FasL protein may be related to the immunological escape of the cancer cell; the expression of ICE was related to the histological grading of the cancer.

关 键 词：凋亡 食管癌 凋亡相关蛋白 

分 类 号：R392.11[医药卫生—免疫学] R735.1[医药卫生—基础医学]