919糖浆抗大鼠肝纤维化的实验研究  

Experimental Study of 919 Syrup Anti-hepatic Fibrosis in Rats

作　　者：黄骏[1] 武哲丽[2] 刘爱华[2] 

机构地区：[1]湖北省十堰市人民医院中医科,湖北十堰442000 [2]湖北中医学院

出　　处：《中西医结合肝病杂志》2003年第3期160-162,共3页Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases

摘　　要：目的:研究919糖浆抗肝纤维化的作用。方法:用CCl_4复合因素制备大鼠肝纤维化模型,同时用919糖浆治疗。以秋水仙碱作为对照,观察其对肝纤维化指标的影响。结果:919糖浆对肝纤维化大鼠有显著降低血清透明质酸(HA),层粘连蛋白(LM),Ⅲ型前胶原(PCⅢ),肝脏羟脯氨酸(Hyp)的作用;通过光镜、电镜观察肝组织病理明显改善。结论:919糖浆具有确切的抗肝纤维化的作用。Objective: To study the effects of 919 syrup on hepatic fibrosis. Methods: Wistar rats' model of hepatic fibro-sis was induced by compound factors of CCl4 and foods of high fat and high cholesterol and low protein. Meanwhile they were protected with 919 syrup or Colohieine as control group. The indexes of hepatic fibrosis were assayed. Results: 919 syrup decreased the level of serum HA、LM、 PCⅢ and hydrosyproline in liver tissue. The proliferation degree of collagenous fibers by light-microscope and electron-microscope. The shpae and structure of cell organells were destroyed obviously. Fat storing cells and Kupffer's cells increased. Collagen fibrosis distributed extensively in the model groups. Conclusion: 919 syrup shows difi-nite protective and therapeutic effect on experimental hepatic fibrosis in model rat.

关 键 词：919糖浆 大鼠 肝纤维化 实验 秋水仙碱 Ⅲ型前胶原 层粘连蛋白 

分 类 号：R285[医药卫生—中药学]