黄芪对蟾蜍离体单一肌梭传入放电的影响  

Effect of Radix Astragali on the discharge of isolated toad muscle spindle

作　　者：唐斌[1] 樊小力[1] 吴苏娣[1] 

机构地区：[1]西安交通大学医学院生理学教研室,陕西西安710061

出　　处：《西安交通大学学报（医学版）》2003年第3期215-217,226,共4页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目 (No .3 0 0 70 83 0 )

摘　　要：目的　探讨黄芪、丹参对肌梭传入放电的影响。方法　用空气隔绝法记录蟾蜍离体单一肌梭的传入放电 ,观察黄芪和丹参注射液对肌梭传入电活动的影响 ,并与琥珀胆碱 (SCh)的作用进行比较。结果　应用 5 0mg·L-1SCh后 ,肌梭的自发放电频率由 (0 .79± 0 .12 )Hz增加至 (12 .2 6± 2 .38)Hz。应用 10 0、2 0 0、30 0mg·L-1黄芪后 ,肌梭的传入放电分别由 (0 .80± 0 .34)Hz、(0 .77± 0 .2 9)Hz、(0 .70± 0 .4 2 )Hz增加至 (13.18± 2 .4 3)Hz、(2 4 .0 3± 4 .0 7)Hz、(36 .17± 5 .83)Hz。丹参注射液对肌梭的传入放电没有作用。结论　黄芪可以使肌梭的传入放电频率显著增加 。Objective To observe the effect of Radix Astragali injection (RAI) and salvia miltiorrhiza bunge injection (SmBI) on afferent discharge of muscle spindle. Methods Using air gap technique,the afferent discharge of isolated toad muscle spindle was recorded. The effects of RAI and SmBI on the discharge rate of muscle spindle were observed, and were compared with that of succinylcholine (SCh). Results After administration of 50?mg·L -1 SCh, the spontaneous discharge of muscle spindle increased from 0.79±0.12?Hz to 12.26±2.38?Hz. After administration of RAI of 100, 200, and 300?mg·L -1 , muscle spindle afferent discharges increased from 0.80±0.34?Hz, 0.77±0.29?Hz, and 0.70±0.42?Hz to 13.18±2.43?Hz, 24.03±4.07?Hz, and 36.17±5.83?Hz, respectively. SmBI showed no effect on afferent discharge of muscle spindle. Conclusion The results showed that RAI has an excitative effect on muscle spindle afferents. The effect of RAI on muscle spindle afferents follows a dose dependent increase.

关 键 词：黄芪注射液 丹参注射液 传入放电 琥珀胆碱 失重性肌萎缩 蟾蜍 离体单一肌梭 

分 类 号：R277.76[医药卫生—中医学]