特发性血小板减少性紫癜患者外周血淋巴细胞亚群和血小板相关抗体变化及临床意义  

The changes of lymphocyte subsets and PAIg in patients with idiopathic thrombocyte purpura

作　　者：吴文仪[1] 俞康[2] 张君丽[2] 沈志坚[2] 胡晓霞[2] 

机构地区：[1]浙江省泰顺县人民医院 [2]温州医学院附属第一医院,浙江温州325003

出　　处：《山东医药》2003年第16期13-14,共2页Shandong Medical Journal

摘　　要：用流式细胞术直接免疫法检测 172例早期特发性血小板减少性紫癜 ( ITP)患者外周血淋巴细胞亚群( CD3、 CD4 、CD8、 CD1 9、 C1 6 、CD56 ) ,EL ISA法检测血小板表面血小板相关抗体 ( PAIg G、PAIg A、PAIg M)。结果显示 ,ITP组与正常对照组比较 CD3、CD4 / CD8显著降低 ( P<0 .0 1) ,CD8增高 ( P<0 .0 5 ) ,CD1 9增高极为显著 ( P <0 .0 1) ;ITP血小板表面 PAIg G、 PAIg A、 PAIg M显著高于对照组 ;CD1 9升高和 CD4 / CD8下降与PAIg G、 PAIg A、 PAIg M增高有显著的相关性。认为淋巴细胞亚群功能和比例失常、To investigate the changes of lymphocyte subsets and PAIg of ITP patients and evaluate their effects on the etiopathological mechanism,CD 3,CD 4,CD 8,CD 19 ,CD 16 and CD 56 of the lymphocyte in the peripheral blood of 172 patients with ITP and 42 normal controls were assayed by FCM PAIgG,PAIgA and PAIgM in platelets were detected by ELISA The result showed the percentage of CD 3 cell and ratio of CD 4/CD 8 cell were significantly lower(P<0 01)in ITP patients than that in normal controls,and the hepercentage of CD 8 and CD 19 rose significantly(P<0 05,P 01) The levels of PAIgG,PAIgA and PAIgM in platelets were significantly higher in ITP patients than that in normal controls(P<0 01) The increasing percentage of CD 19 cell and decreasing ratio of CD 4/CD 8 cell were significantly correlated with the levels of PAIgG,PAIgA and PAIgM in ITP patients(P<0 01) These suggest the abnormal function and ratio of lymphocyte subsets as well as the immunologic mechanism disorder of T lymphocytes play important roles in etiopathological mechanism of ITP

关 键 词：特发性血小板减少性紫癜 外周血淋巴细胞亚群 血小板相关抗体 流式细胞术 直接免疫法 检测 

分 类 号：R554.6[医药卫生—血液循环系统疾病]