PVP K30对葛根黄豆苷元增溶的研究  

Effect of PVP K30 on Solubility of Daidzein

作　　者：郭丽[1] 郭圣荣[1] 赵凤生[1] 

机构地区：[1]上海交通大学药学院,上海200030

出　　处：《中国医药工业杂志》2003年第6期273-275,共3页Chinese Journal of Pharmaceuticals

摘　　要：研究了葛根黄豆苷元 (1)在不同温度、不同浓度的 PVP K3 0 -磷酸盐缓冲液中的溶解度 ,1溶解度随辅料浓度的增大而明显增大。溶解度数据经热力学方法处理 ,表明这是个自发过程。采用溶剂法 ,以 PVP K3 0为载体制备 1固体分散体 ,考察固体分散体中 1的溶解度和溶出度。与其本身相比 ,固体分散体中 1溶解度显著提高 。It was found that the solubility of daidzein in PVP K30 phosphate buffer solution increased significantly as PVP concentration increased. The solution was a spontaneous process according to the thermodynamic theory. Daidzein solid dispersions with PVP K30 were prepared by co evaporation. Compared with the pure daidzein, the dissolution rate and solubility of the drug in solid dispersions were considerably enhanced.

关 键 词：葛根黄豆苷元 PVP K30 溶解度 溶出度 固体分散体 

分 类 号：R94[医药卫生—药剂学]