复方黄芪合剂对早期DN模型鼠Col-Ⅳ及MMP-2/TIMP-2的影响  

Influence of "Compound Huangqi Mixture" on Col-Ⅳ and MMP-2/TIMP-2 in Early DN Rats

作　　者：贺学林[1] 陈以平[2] 邓跃毅[2] 张志刚[3] 郭慕依[3] 

机构地区：[1]浙江大学医学院附属第一医院肾脏病中心,浙江杭州310003 [2]上海中医药大学附属龙华医院肾内科,上海200032 [3]复旦大学上海医学院病理教研室,上海200032

出　　处：《上海中医药杂志》2003年第6期51-54,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市卫生局资助项目 (9940 7)

摘　　要：为研究复方黄芪合剂 (主药 :黄芪、牛蒡子 )治疗DN的疗效与机理 ,4 5只大鼠以STZ诱导造成糖尿病模型 ,3d后分为 3组 ,B组给予复方黄芪合剂 ( 5g·kg- 1·d- 1)、C组给予洛汀新 ( 4mg·kg- 1·d- 1)药液灌胃 ,D组予等量生理盐水灌胃 (模型组 ) ,另一组大鼠为对照组 (A组 ) ,不作任何处理。 6周后比较各组大鼠的有关指标。结果 :B、C组大鼠的Ccr、Ualb、肾脏基质阳性面积比、Col Ⅳ、MMP 2、TIMP 2诸项指标均高于D组 ,其中GLU、HbAlc、Ccr三项指标B组优于C组。提示 :降低肾脏Col Ⅳ、MMP 2 /TIMP 2的表达 。To study the clinical efficacy and mechanism of 'Compound Huangqi Mixture'(CHM),45 rats were modeled with STZ into diabetic nephrosis and then randomized into three groups 3 days later. Group B was given 5g/kg·d -1 of CHM,group C was given 4mg/kg·d -1 of Lotensin and group D which was given equal amount of normal saline.Another 15 rats in group A with no treatment were used as control.The measurements were conducted 6 weeks later.Results:Ccr,Ualb,stromal positive area ratio,Col-Ⅳ,MMP-2 and TIMP-2 were higher in groups B and C than in group D,with better GLU,HbAlc and Ccr in group B than in group C.It is indicated that the Mixture may reduce Col-Ⅳ,MMP-2 and TIMP-2 to treat early diabetic nephosis.

关 键 词：复方黄芪合剂 早期 DN模型鼠 Col—Ⅳ MMP—2/TIMP—2 影响 

分 类 号：R285.5[医药卫生—中药学]