实验性胰腺炎时核因子-κB与p^(53)、bcl-2表达的关系  

Expression of NF-κB,p^( 53) and bcl-2 on experimental pancreatitis

作　　者：裴红红[1] 秦兆寅[1] 李小珍[1] 杨正安[1] 封英群[1] 

机构地区：[1]西安交通大学第二医院急诊外科,710004

出　　处：《中国急救医学》2003年第6期375-376,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　探讨实验性胰腺炎时核因子 -κB与p53 、bcl- 2之间的关系。方法　 35只SD大鼠被随意分成对照组(7只 ) ,急性水肿型胰腺炎 (AEP)模型组 (1 4只 ) ,急性坏死型胰腺炎 (ANP)模型组 (1 4只 )。制成ANP模型及AEP模型 ,应用免疫组化的方法计算胰腺组织中p53 、bcl- 2表达的阳性率。结果　AEP组p53 表达阳性率强于ANP组表达阳性率 (P <0 0 5 ) ,AEP组bcl- 2表达阳性率则弱于ANP组表达阳性率 (P <0 0 5 )。结论　NF -κB、p53 、bcl-Objective To explore the relationship between nuclear factor-κB(NF-κB),p 53 and bcl-2 on experimental pancreatitis.Methods 35 SD rats were randomly divided into control group,acute edematous pancreatitis group,acute necrotizing pancreatitis group.The rats model of AEP and ANP were made.Expression of p 53 and bcl-2 in pancreatic tissue of the three groups were observed by immunohistochemistry.Result The expression of p 53 in AEP group was more obvious than that in ANP group(P<0 05),and bcl-2 in AEP group was milder than that in ANP group (P<0 05).Conclusion The NF-κB,p 53 and bcl-2 were involved in the inflammation process and apoptosis of experimental pancreatitis.

关 键 词：胰腺炎 实验性 NF—KB p533 bE—2 

分 类 号：R657.51[医药卫生—外科学]