复方高渗液抗创伤失血性休克初步研究  

Primary study on the effect of compound hyperosmotic fluid on anti-hemorrhagic shock

作　　者：高世义[1] 高海[1] 狄思懋[1] 徐伟[1] 刘光汉[1] 陶宝华[1] 王洪[1] 王荣升[1] 郁晓明[1] 

机构地区：[1]上海市第六人民医院急救科,200233

出　　处：《中国急救医学》2003年第6期384-385,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　观察高渗氯化钠羟乙基淀粉 4 0注射液 (HypertonicSodiumChlorideHydroexythlstarch 4 0injection ,简称“复方高渗液”)Ⅱ期临床试验中的抗失血性休克效果。方法　选择创伤性失血性休克病人 1 5例 ,收缩压均低于 90mmHg。“复方高渗液”的输入速度 1 2 5～ 2 5mL/min ,平均 1 6 6 7mL/min。结果　输入后 4～ 5min血压即开始上升。至用药结束 ,休克病人的血压明显升高 (P <0 0 1 ) ,收缩压、舒张压的平均增幅分别为 (31 31± 9 91 )mmHg及 (9 6 2± 7 98)mmHg ;心律及呼吸也有明显改善 (P <0 0 5 ) ;病人的尿量达 (2 1 4± 1 1 2 )mL·kg-1 ·h-1 。病人平均用药量 (393 0 8± 1 0 5 4 7)mL。平均给药时间(2 3 0 8± 5 2 2 )min。观察 2 4h ,未见有不良事件发生。结论　“复方高渗液”Objective This article had studied the effect of hyperosmotic-Nacl-ethoxylamylum 40 injection fluid(simply named'compound hyperosmotic fluid') on anti-hemorrhagic shock during the second period of the clinical experiment. Methods 15 patients whose average age was 40 92±12 43 and systolic pressure was under 90 mmHg had been chosen.When the injection rate was 12 5～25 mL/min(the average rate was 16 67 mL/min),the blood pressure began to rise after 4～5 minutes injection.Results When the injection was over,the blood pressure of these patients had risen evidently.Systolic pressure and diastolic pressure rose (31 34±9 91)mmHg and (9 62±7 98)mmHg respectively.The rhythm of heart and respiration had also been improved(P<0 05).Urine volume of these patients was(21 4±1 12)mL·kg -1 ·h -1 .The average injection volume was (393 08±105 47)mL.The average injection time was (23 08±5 22)minutes.During a 24-hour observation,no side-effect had happened.Conclusion The result showed that'compound hyperosmotic fluid' had a good effect on anti-hemorrhagic shock.

关 键 词：复方高渗液 抗体克 

分 类 号：R605.971[医药卫生—急诊医学]