阿西美辛脂质体凝胶剂的体外透皮扩散研究  

Study on transdermal diffusion action of acemetacin liposome gel

作　　者：李冬梅[1] 路绪文[1] 苏芳[2] 

机构地区：[1]中国人民解放军第251医院,河北张家口075000 [2]中国人民解放军白求恩军医学院

出　　处：《中国医院药学杂志》2003年第6期330-333,共4页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :研究阿西美辛 (ACM)脂质体凝胶剂的体外透皮扩散。方法 :采用Franz扩散池 ,离体鼠皮 ,分别考察不同时间点阿西美辛脂质体凝胶剂与阿西美辛凝胶剂的体外透皮量、皮肤层滞留量、凝胶层滞留量 ,并对两种制剂的体外透皮规律进行拟合 ,得出规律方程。结果 :阿西美辛脂质体凝胶剂与阿西美辛凝胶剂的透皮扩散行为差异有显著性。前者可显著提高药物的透皮药量 ,2 4h时累积透过药量约 4 0 % ,且在皮肤层内的滞留量多于ACM凝胶剂 ;而ACM在非包封状态下 ,不易穿透皮肤 ,大部分仍存在于凝胶剂中。结论 :阿西美辛脂质体凝胶剂可显著提高药物的透皮量 ,有望成为阿西美辛的一种外用新剂型。OBJECTIVE To study the transdermal diffusion action of acemetacin liposome gel.METHODS Amended Franz diffusion cell and rats skin were used to compare the percutaneous penetration of ACM liposome gel and ACM gel in vitro at different time fitting the percutaneous equation of ACM liposome gel. RESULTS There was significant difference between the percutaneous action of the two preparations. The acemetacin liposome gel can improve significantly the permeability of the acemetacin with a larger deposited amounts of acemetacin in the skin. The permeability of non-liposomal acemetacin through the rats skin was poor. CONCLUSIONS Liposome gel can be used as a carrier of acemetacin in the skin application that increases the permeability through the rat skin.

关 键 词：阿西美辛 脂质体 凝胶剂 透皮扩散 HPLC 

分 类 号：R927[医药卫生—药学]