糖皮质激素对弥漫增生型狼疮性肾炎血清TGF-β_1的影响  

The effect of glococorticoid in treatment of class IV lupus nephritis

作　　者：罗萍[1] 李艳辉[1] 顾华[1] 卢雪红[1] 苗起芬 

机构地区：[1]吉林大学第二医院,长春130041 [2]长春市中心医院,长春130051

出　　处：《中国免疫学杂志》2003年第6期429-430,共2页Chinese Journal of Immunology

摘　　要：目的 :通过对弥漫增生型狼疮性肾炎 (LN)糖皮质激素治疗前后血中转化生长因子 β1 (TGF β1 )含量测定 ,了解糖皮质激素在治疗弥漫增生型LN中的作用。方法 :用ELISA方法检测正常对照组 (n =15 )及弥漫增生型LN组 (n =18)血清中TGF β1 水平。结果 :弥漫增生型LN组糖皮质激素冲击治疗后TGF β1 水平明显降低。结论 :弥漫增生型LN及时应用足量的糖皮质激素 ,可能会延缓硬化性肾炎的发生。Objective:To investigate the effect of glucocorticoid on treating class IV lupus nephritis(LN) by comparing the content of serum transforming growth factor beta(TGF β 1).Methods:The study consisted of 33 objects,15 health controls as well as 18 cases of IV LN.The level of serum TGF β 1 was analyzed by ELISA.Results:The level of serum TGF β 1 was greatly reduced after the patients were treated with glucorcorticoid.Conclusion:Timely and sufficient glucocorticoid may prevent IV LN from developing into glomerulosclerosis.

关 键 词：糖皮质激素 弥漫增生型狼疮性肾炎 血清 TGF-Β1 影响 

分 类 号：R593.242[医药卫生—内科学]