司帕沙星的单扫示波极谱法  

Single Sweep Oscillopolarography of Sparfloxacin

作　　者：曾泳淮[1] 高红艳[1] 

机构地区：[1]北京师范大学化学系,北京100875

出　　处：《分析科学学报》2003年第3期243-245,共3页Journal of Analytical Science

摘　　要：在 0 .2 mol·L- 1KH2 PO4 - K2 HPO4 ( p H6.80 )底液中 ,用单扫示波极谱法可以得到一个灵敏的司帕沙星导数还原峰 ,其峰电位 Ep=- 1 .43V( vs.SCE) ,导数峰电流与司帕沙星浓度在 0 .1～ 8.0μmol· L- 1范围内呈线性关系 ,检出限为 0 .0 5μmol· L- 1。该法应用于模拟尿样和胶囊中司帕沙星质量含量的测定 ,结果满意。In a supporting electrolyte containing KH 2PO 4 K 2HPO 4 at pH 6.80, a sensitive derivative reduction peak of sparfloxacinis was observed by single-sweep oscillopolarography. The peak potential was -1.43 V(vs.SCE). The relationship between the peak current and the concentration of sparfloxacinis was linear in the range of 0.1~8.0 μmol·L -1 ( r =0.9994). The detection limit was 0.05 μmol·L -1 . The method was applied to the determination of sparfloxacinin in tablet and urine with satisfactory results. The electrochemical behavior of sparfloxacinat Hg electrode was also explored.

关 键 词：司帕沙星 单扫示波极谱法 电化学行为 抗菌药 药物分析 

分 类 号：TQ465[化学工程—制药化工] R978.1[医药卫生—药品]