参麦注射液对^(60)Co照射小鼠血液系统作用的研究  

The effect of Shenmai injection on the blood system of^(60)Co irradiated mice

作　　者：周冠强 杨芳炬[2] 朱玲[2] 刘之光[2] 李嘉豪[2] 植茂辉[2] 

机构地区：[1]北海中医院,北海536000 [2]四川大学华西基础医学与法医学院,成都610041

出　　处：《四川生理科学杂志》2003年第1期32-34,共3页Sichuan Journal of Physiological Sciences

摘　　要：目的 :观察参麦注射液 (SMI)对于放射性损伤所致的小鼠血虚证的治疗作用。方法 :采用6 0 Co照射小鼠 ,造成小鼠白细胞减少模型 ,即产生小鼠血虚证。评价SMI对于6 0 Co所致的小鼠血虚证的治疗作用。结果 :SMI对6 0 Co照射所致小鼠血虚证症状如虚汗多、寒战、精神萎靡有一定程度的抑制作用 ,尤其对6 0 Co照射所致小鼠外周血白细胞和骨髓有核细胞数的减少有明显对抗作用 ,与模型组比较有显著性差异 (P <0 .0 5 )。试验还显示 ,照射后四天SMI大、中剂量组小鼠骨髓有核细胞数与阴性对照组无显著性差异 ,说明其骨髓造血功能比较活跃 ,提示SMI对放射性损伤所致小鼠血虚证有一定的保护和治疗作用 ,对于小鼠白细胞减少有较好的治疗效果。结论 :SMI对小鼠放射性损伤所致血虚证有一定的保护和治疗作用。Objective: To study the effects of Shenmai injection (SMI) on irradiated damage in blood system of mice. Methods: models of leucocytopenia induced by irradiation were prepared by 60 Coγ ray. Result: The results were showed that SMI had inhibited action on sweat, chill, spirit sag and especially had therapeutic effects on leucocytopenia in peripheral blood and reduces of nucleus cells in marrow irradiated blood system damage induced by 60 Co. Conclusion: SMI had protection and therapeutic effects on leucocytopenia of mice induced by irradiation.

关 键 词：参麦注射液 ^60CO照射 小鼠 血液系统作用 研究 血虚证 放射性损伤 白细胞减少 

分 类 号：R285[医药卫生—中药学]