硫酸链霉素的单扫描示波极谱法测定  

Determination of streptomycin sulfate by single sweep oscillopolarography

作　　者：刘利民[1] 郭新春[1] 刘锋[2] 

机构地区：[1]井冈山师范学院,化学系,江西,吉安,343009 [2]吉安市第三中学,江西,吉安,343000

出　　处：《井冈山师范学院学报》2003年第5期29-31,40,共4页

摘　　要：建立了测定硫酸链霉素的新方法.在O.5moL/L NH3-NH4Cl(pH 10.4)缓冲溶液中,硫酸链霉素产生两个还原波,峰电位分别为-1.44V和-1.55V,其中-1.55V处还原波的二阶导数峰电流与硫酸链霉素浓度呈线性,线性范围为250～1100μg/mL,检测下限为200μg/mL.该方法用于注射液中硫酸链霉素含量的测定,结果满意.A new method was established to determine streptomycin sulfate. In 0.5mol/L NH3-NH4Cl(pH 10.4)buffer solution, streptomycin sulfate yielded two reduction waves with peak potential of -1.44 and -1.55V (vs.SCE) respectively. The second-order derivative peak current of the reduction wave at -1.55V was linearly proportional to streptomycin sulfate concentration in the range of 250-1100μg/ ml,and the determination limit was 200μg/mL. This method was used to test streptomycin sulfate content in streptomycini sulfate pro injictione, with satisfactory results.

关 键 词：硫酸链霉素 单扫描示波极谱法 测定 注射液 氨基酸糖苷 抗生素 

分 类 号：R978.12[医药卫生—药品] R927.2[医药卫生—药学]