有机锗(Ge—132)的免疫调节作用  

A STUDY ON THE IMMUNOREG ULATION EFFECT OF CARBOX—YETHYL GERMANIUM SESGIOXIDE(GE—132)

作　　者：党锡连[1] 司传平[1] 于江[1] 杨靖[1] 衣美英[1] 

机构地区：[1]济宁医学院微生物学教研室

出　　处：《济宁医学院学报》1992年第3期27-29,共3页Journal of Jining Medical University

摘　　要：本文对羧乙基锗倍半氧化物(GB—132)的免疫调节作用进行了人体和动物实验研究,结果显示,Ge—132在人体内可诱导产生干扰素和增强NK 细胞活性。20名健康成人口服合锗饮料后,血清干扰素含量(单位)由口服含锗饮料前的5.6±2.08上升至61.6±34.05(P<0.001);NK 细胞潘性由口服含锗饮料前的19.7±8.69%上升至32.25±10.79%(P<0.001)。Ge—132还可增加小鼠腹腔巨噬细胞吞噬氧化活性,对照组小鼠巨噬细胞吞噬氧化活性(发光强度)为167.71±59.27,实验组为931.43±311.84(P<0.001)。In this report,the immunoregulation effect of carboxyethyl germa-ium sesquioxide(Ge-132)was studied in human and animal bodies.The result sho-wed that the titers of IFN and NK cell activity of 20 normal adults after oraladministration of Ge-132(100mg/day×10)were increased significantly.In addition,the enhancement of phagocytosis and oxiative activdity of peritoneal macrophagesby Ge-132 was observed in mice.The above results suggest that Ge-132 has an ob-vious immunoregulation effect.

关 键 词：免疫调节 有机锗 

分 类 号：R979.5[医药卫生—药品]