口服有机锗(Ge—132)尿药排泄规律的研究  

DETERMINATION OF GERMANIUM IN URINE AND STUDIES ON PHARMACOKINETICS OF Ge—132 IN BODY

作　　者：陈雁君[1] 王宁[1] 上官国强[1] 陈亚民[1] 

机构地区：[1]济宁医学院化学教研室

出　　处：《济宁医学院学报》1992年第4期14-16,共3页Journal of Jining Medical University

摘　　要：应用胶束增溶苯基荧光酮分光光度法测定了尿中锗,研究了成人口服Ge—132后尿药的排泄规律。测尿中锗的平均回收率为98.1～104.3%,不同浓度测定结果的日内和日间变异系数均小于5%,检出限为0.012μg/ml。主要药动学参数Ka0.451h^(-1):K0.292h^(-1):tmax2.73h。Determination of germanium with spectrophotometry of phenyl-fluorones in urine and studies on pharmacokinetics of Ge—132 in body were repor-ted.The main pharmacokinetiee parameter was Ka 0.451h^(-1),K 0.292h^(-l),tmax 2.73h.The average recoveries of germanium added to urine was in the range of 98.1-104.3%.The relative standard deviations were less than 5%.

关 键 词：药物动力学 分光光度法 有机锗 

分 类 号：R977.9[医药卫生—药品]