佛甲草对四氯化碳中毒小鼠的抗脂质过氧化作用研究  

The Effects of Sedum Iineare Thunb on Anti-Iipid Peroxidation Induced by CCl_4 in Mice

作　　者：周青[1] 许庆林[2] 周俐[1] 连其深[1] 张晓英[1] 曾爱萍[1] 刘建新[1] 

机构地区：[1]赣南医学院 [2]赣南医学院附属医院,江西赣州341000

出　　处：《赣南医学院学报》2003年第2期128-130,共3页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：目的 :探讨佛甲草提取液对四氯化碳中毒小鼠肝损伤的保护作用机制。方法 :采用四氯化碳致小鼠肝损伤 ,测定小鼠血清、肝组织中MDA含量及SOD活性。结果 :四氯化碳可使小鼠血清、肝组织MDA含量升高 ,SOD活性下降 ;佛甲草提取液明显降低四氯化碳中毒小鼠血清、肝组织MDA含量 (P <0 .0 1)及升高SOD的活性 (P <0 .0 1)。结论 :佛甲草提取液对四氯化碳中毒小鼠肝损伤的保护作用与其抗脂质过氧化有关。objective:The mechanism of extractive isolated from sedum lineare thunb was observed on the preventing from hepatic injury induced by CCl 4 in mice.Method:The content of MDA and activity of SOD in mice serum and in liver tissue were assessed respectively.Result:It was showed that the extractive could marked inhibit the increasing of content of MDA and increase activities of SOD( P <0.01),respectively induced by CCl 4 in mice serum and in liver tissue.Conclusion:The extractive of sedum lineare thunb preventing from hepatic injury induced by CCl 4 is due to anti lipid peroxidation.

关 键 词：佛甲草 四氯化碳 MDA SOD 

分 类 号：R965[医药卫生—药理学]