3-甲氧基-1-丙醇的合成  

Synthesis of 3-Methoxy-1-propanol

作　　者：李复生[1] 魏东炜[1] 崔金华[1] 殷金柱[1] 

机构地区：[1]天津大学石油化工技术开发中心,天津300072

出　　处：《化学反应工程与工艺》2003年第2期141-144,共4页Chemical Reaction Engineering and Technology

摘　　要：　由3-氯-1-丙醇法合成3-甲氧基-1-丙醇确定的较佳工艺条件为:甲醇钠/3-氯-1-丙醇摩尔比=1.4～1.8,甲醇钠的甲醇溶液质量分数=27%～30%,滴加温度及反应温度均为70℃,滴加时间为1h,反应时间为5h,并确定了中和方法及精馏提纯条件。产品收率在85%以上,较文献报道产品收率有明显提高。3methoxy1propanol was synthesized from 3chloro1propanol. The optimum conditions of methoxy substitution reaction were determined as that the mole ratio of sodium methylate to 3chloro1propanol is 1.4~18, the mass content of sodium methylate in methanol solution is 27%~30%, 3chloro1propanol drops off 1h at reaction temperature of 70℃, and the reaction time is 5h. The yield was over 85% which is better than that reported in literatuies.

关 键 词：3-甲氧基-1-丙醇 合成 3-氯-l-丙醇法 甲氧基取代 药物中间体 

分 类 号：TQ463.23[化学工程—制药化工]