氯化胆碱合成工艺的研究  

Study on Synthesizing Technology of Choline Chloride

作　　者：崔玉民[1] 杨高文[2] 

机构地区：[1]阜阳师范学院化学系,安徽阜阳236032 [2]常熟理工学院科学与材料系,江苏常熟215500

出　　处：《化学反应工程与工艺》2003年第2期155-159,共5页Chemical Reaction Engineering and Technology

基　　金：安徽省教育厅自然科学基金资助项目(2002kj235);常熟理工学院科研计划基金资助(2002SH06)

摘　　要：　在氯化胆碱的作用下,三甲胺与氯乙醇反应合成氯化胆碱。讨论了影响产品收率及纯度的主要因素。实验发现氯化胆碱有自催化作用,在优化工艺条件下,氯化胆碱的收率达到95.8%,纯度达到98.0%。该工艺具有操作简单、易分离、易干燥、收率高、纯度高、成本低、易推广等优点。Choline chloride was synthesized from the reaction of trimethlamine and chloride ethanol in the present of choline chloride.The primary factors which affect the yield and the purity of product were discussed.By means of experiments, it was found that Choline Chloride has self catalytic action. Under the optimum conditions, the yield and the purity of choline chloride could reach to 95.8% and 98.0%,respectively.The process has advantages of simplified operation,easy separating,easy drying,high yield and purity,low cost and easy application and dissemination et al. [WT5HZ]

关 键 词：氯化胆碱 合成工艺 三甲胺 氯乙醇 自催化作用 工艺 氯化三甲基羟乙基铵 维生素B属药物 

分 类 号：TQ466.2[化学工程—制药化工]