糖尿病肾病从“毒损肾络”辨治理论体系探要  

Search For The Theory System Which Diabetic Nephropathy Treat ment According To Syndrome Different From“Toxicity Injures Nephropathy Meridian Collaterals”

作　　者：邓悦[1] 王宏[1] 南征[1] 

机构地区：[1]北京中医药大学博士生,北京,100029

出　　处：《中医药学报》2003年第3期2-3,共2页Acta Chinese Medicine and Pharmacology

摘　　要：糖尿病肾病是由于糖尿病 (消渴病 )迁延不愈 ,燥热化毒 ,毒损肾络而成。其发生和发展是由于肾组织糖代谢紊乱、脂代谢紊乱、高血压、血管活性物质、生长因子与化学趋化因子、反应氧中间产物和遗传因素等综合作用的结果。肾小球细胞外基质积聚与糖尿病肾病密切相关 ,是许多肾小球病变发生机制中的一个重要环节和共同病理特征。治疗上据其“毒损肾络”的病机特点 ,宜解毒通络 ,补肾固本 ,并结合病期而辨治 ,尽早应用 ,防微杜渐 ,真正做到“已病防变”和“未病先防”。The diabetic nephropathy is because the diabetes mellitus (xiao ke disease)can't be fully recovered for a long time,The dryness and heat become toxicity,and toxicity injures the kidney meridian collaterals.The modern pathology foundation is the toxicity of carbohydrate and the toxicity of fat ect.They lead to increase about extracelluler matrix.To say in a specific way,its occurrence and development is the result,which metabolic disturbance of carbohydrate and fat of the kidney organize,hypertension,vascular active substarce,growth factor,chemotactic factor,reactive oxygen species,heredity factor ect synthesize the functions.Accumulating extracellular matrix of glomerulus is closely related to diabetic nephropathy.It is an important lank and the general pathologic character within occurrence mechanism about the pathological change of glomerulus.In treatment,we should dissolue toxicity and remove obstraction in the channels,supplement the kidney and firm the root,according to pathogenesis about “toxicity injures the kidney meridian collaterals”,and treatment according to syndrom differentation is coupled with the coures of disease,apply it as early as possible,nip an evil in the bud,really attain to “defend to change who are already ill”and “defend first who are not ill”.Author's address:Beijing University of Traditional Chinese Medicine,Beijing 100029,China

关 键 词：糖尿病肾病 毒损肾络 中医药疗法 辩证论治 扶正祛邪 补肾解毒通络法 

分 类 号：R259.872[医药卫生—中西医结合]