毛叶香茶菜中的二萜化合物(英文)  

Diterpenoids from Isodon japonicus

作　　者：韩全斌[1] 张积霞[2] 沈云亨[1] 孙汉董[1] 

机构地区：[1]中国科学院昆明植物研究所植物化学和西部植物资源持续利用国家重点实验室,昆明650204 [2]新乡医学院化学教研室,新乡453000

出　　处：《中国天然药物》2003年第1期16-20,共5页

摘　　要：目的:对河南产毛叶香茶菜化学成分进行研究。方法:运用各种色谱技术和波谱分析对其化学成分进行分离鉴定。结果:分离鉴定了20个二萜化合物。结论:化合物1-3为三个新的对映-贝壳杉烷二萜类化合物,结构分别为7β-15β,16β三羟基-6β,17β二乙酰氧基-7α,20-环氧-对映-贝壳杉烷(1)、16(S)-6β,11α,17p三羟基一6,20一环氧一la,7β内酯-6,7-断裂-对映-贝壳杉-15酮(2)和6α,11α二羟基-1α乙酰氧基-7,20-内酯-6,7-断裂-对映-贝壳杉-16-烯-15-酮(3),依次命名为毛叶香茶莱丙素、丁素和戊素;化合物4和5为一对新化合物,其结构为3α,15α,1β6,17β,18β五羟基-对映-松香-7(8)-烯的丙酮化物,其丙酮化缩合部分互为对映体,分别命名为毛叶香茶菜庚素(4)和辛素(5)。AIM:To study the chemical constituents of Isodon japonicus. METHOD: We isolated and elucidated the chemical constituents using chromatographic techniques and spectral analysis. RESULT and CONCLUSION: Twenty diterpenoids including three new eni-kauranoids (1-3) and a pair of epimers of new ent-abietanoid (4 and 5) were isolated and identified. These five new diterpenoids are 7β, 15β, 16β-trihydroxy-6β, 17-diacetoxy-7a, 20-epoxy-ent-kaurane (1) , 16( S)-6β, 11a 17-trihydroxy-6,20-epoxy- 1a, 7-olide-6, 7-seco-ent-kaur-15-one (2), 11a-dihydroxy-la-acetoxy-7,20-olide-6,7-seco-ent-kaur-16-en-15-one (3) , 15(S)-3a, 17, 18-trihydroxy-ent-abieta-7(8)-en-15, 16-acetonide (4), 15( R)-3a, 17, 18-trihydroxy-ent-abieta- 7(8)-en-15,16-acetonide (5) , and named maoyecrystals C-E, G and H, respectively. The I3C NMR data of lasiokaurin (13) is reported in this paper for the first time.

关 键 词：毛叶香茶菜 二萜化合物 化学成分 中药 

分 类 号：R284.1[医药卫生—中药学]