Isoline两个新代谢物的制备及其理化性质(英文)  

Preparation and Characterization of Two New Metabolites of Isoline

作　　者：汤俊[1] 张勉[1] 王峥涛[1] 赤尾光昭 中村■夫 服部征雄[3] 徐国钧[1] 

机构地区：[1]中国药科大学生药学研究室,南京210038 [2]日本国富山医科药科大学和汉药研究所药学部 [3]日本国富山医科药科大学和汉药研究所

出　　处：《中国天然药物》2003年第1期21-23,共3页

基　　金：国家自然科学基金杰出青年基金资助项目(No.39825129)~~

摘　　要：目的:为进一步研究isoline的代谢和毒理,采用化学方法制备其代谢产物。方法:分别采用水解,氮氧化和脱氢化反应将isoline转化为与代谢和毒理研究相关类型的产物。结果与结论:成功地制备了五个化合物,其中两个为新化合物,其结构经UV,IR,MS和NMR分析得以鉴定。AIM: To prepare the metabolic compounds of isoline for further investigation of its metabolism and toxicology. METHODS:The improved chemical procedures involving hydrolysis, N-oxidation and dehydrogenation were used to convert isoline to the compounds of closely related structural types, which may be formed by in vivo enzyme systems. RESULT and CONCLUSION: Five compounds were successfully prepared from isoline, in which two new compounds were determined as isoline N-oxide and dehydro-isoline by UV,IR,MS and by extensive use of NMR techniques.

关 键 词：Isoline 代谢物 制备 理化性质 毒理 

分 类 号：R965.1[医药卫生—药理学]