血管紧张素Ⅱ对雄性大鼠下丘脑GGT活性的影响  

Effect of AngⅡ on hypothalamic GGT activity in male rats

作　　者：华文浩[1] 马虹宇[2] 王京花[1] 阎彬彬[1] 曹兴福[1] 张颖[1] 

机构地区：[1]哈尔滨医科大学生理学教研室,黑龙江哈尔滨150086 [2]黑龙江省医院检验科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2003年第3期206-207,210,共3页Journal of Harbin Medical University

摘　　要：目的　观察脑室微量注射血管紧张素Ⅱ (AngⅡ )对雄性大鼠下丘脑γ 谷氨酰转肽酶 (GGT)活性变化的影响。方法　应用速率法分析测定下丘脑组织GGT活性。结果　脑室微量注射血管紧张素Ⅱ (0 .12 μg 2 0 μl)使下丘脑GGT活性明显增加 (P <0 .0 5 ) ,此作用可被AngⅡ受体拮抗剂Saralasin所阻断。结论　AngⅡ可能通过兴奋AT1 受体增强下丘脑组织GGT的活性 ,促进氨基酸转运至下丘脑促性腺激素释放激素 (GnRH)神经元内 ,参与GnRH蛋白质的合成 。Objective To study the effect of angiotensinⅡ(AngⅡ) on hypothalamic γ glutamyltransferase (GGT) activity of male rat with intracerebroventricularly (icv) injection.Methods The hypothalamic GGT activity was analyzed by rate method. Results After icv injection of AngⅡ(0.12 μg / 20μl ) 60min, the activity of hypothalamic GGT was significantly higher than that in control( P <0.05)and the action could be blocked by saralasin (specific AT 1 receptor antagonist of AngⅡ).Conclusion The results suggest that AngⅡ could increase hypothalamic GGT activity by affecting AT 1 receptor, accelerating amino acid to transmit into neuron of gonadotropin releasing hormone (GnRH), promoting the synthetic process of GnRH and increasing the content of hypothalamic GnRH peptide finally.

关 键 词：血管紧张素Ⅱ 雄性大鼠 下丘脑 GGT活性 影响 

分 类 号：R338.24[医药卫生—人体生理学]