内蒙高原实验性爆炸伤某些病理生化改变与防护效果观察  

MORPHOLOGICAL AND BIOCHEMICAL CHANGES FOLLOWING EXPERIMENTAL EXPLOSIVE INJURY IN INNER MONGOLIA HIGHLAND AND THE PROTECTIVE EFFECT AGAINST EXPLOSION

作　　者：狄凤桐[1] 狄宁 王正国[3] 杨志焕[3] 张永靖[1] 白小清[1] 何福全[1] 

机构地区：[1]解放军第二五三医院,呼和浩特010051 [2]内蒙陆军预备役部队 [3]第三军医大学野战外科研究所

出　　处：《解放军预防医学杂志》2003年第3期170-172,共3页Journal of Preventive Medicine of Chinese People's Liberation Army

摘　　要：目的 :观察内蒙高原条件下实验性声波冲击波伤复合火药中毒对动物组织形态学及某些生化指标的影响 ,为临床防护提供依据。方法 :用爆竹爆炸致伤 30只兔 ,用手榴弹炸伤鱼2 3尾 ,伤后作病理学检查 ,测定凝血酶元时间以及SOD、MDA。另 10只兔在采用自制防护装具和口服战伤 1号条件下进行陆地爆炸时防护效果观察。结果 :陆地和水下爆炸实验动物死亡率分别为 4 3%和 6 5 %。解剖发现动物脑、脊髓呈血瘀症改变以及胃出血 ,胸腔积血 ,肺破裂出血 ,胆囊、脾破裂出血。光学显微镜检查脑、脊髓细胞肿胀 ,血管内壁细胞肿胀 ,血流阻塞 ;凝血酶元时间延长 ;SOD降低 ,MDA升高。采用防护措施后 ,10只兔死亡 1只 ,解剖 3只发现脑轻度肿胀充血 ,肺挫伤 ,胆囊、胃、脾肿胀充血无破裂 ,其余 6只兔经急救处理后成活。结论 :实验性声波冲击波伤复合火药中毒可致组织形态严重损伤和某些生化改变 ,采用防护措施可预防爆炸时组织损伤 ,减少死亡率。Objective: To observe the effect of sound wave and blast injury combined with gun-powder poisoning on morpbological and biochemical changes of the animals in Inner Mongolia highland regions, so as to provide scientific basis for clinical protection.Methods: 30 rabbits were injured by firecrackers in land explosion experiment and 23 fishes by grenade in water cxplosion experiment. Then pathological examination was performed and SOD, MDA, prothrombin time(PT) were measured. Protective effect was observed in 10 rabbits by using self-developed eguipment and taking medicine(War Injury Agent No1). Results:The animal death rate in land and water explosion were 43% and 65% respectively. Pathological examination showed cerebro-spinal congestion, gastric hemorrhage, thoracic blood accumulation, rupture and bleeding in lung, gall-bladder and spleen.Microscopic examination showed swelling of cerbo-spinal cells and endothelial cells. PT was prolonged and SOD activity of muscle was decreased, while MDA content was increased. Only one of the protected rabbits died (1/10) and congestion, swellimg in brain, spinal cord, lung, stomach and in gall-bladder but no rupture were found in 3 rabbit dissection. The rest of 6 protected rabbits all survived. Conclusion: Sound wave and blast injury combined with gun-powder poisoning may cause severe tissue damage and some biochemical change. Using protective measures could reduce the injury and death rate.

关 键 词：内蒙高原 声波 冲击波伤 火药中毒 爆炸 

分 类 号：R642[医药卫生—外科学] R595[医药卫生—临床医学]