凋亡相关基因Bcl-2、Bax在相对静息期增生性瘢痕、瘢痕疙瘩中的表达及分布  

Expression and histological distributive characteristic of apoptosis related gene Bcl-2 gene and Bax gene in relative resting hypertrophic scar and keloid

作　　者：周智[1] 李荟元[1] 马福臣[2] 鲁开化[1] 张传山[2] 胡佩珍[2] 

机构地区：[1]第四军医大学西京医院整形外科,陕西西安710032 [2]第四军医大学西京医院病理科

出　　处：《实用美容整形外科杂志》2003年第3期160-162,共3页Journal of Practical Aesthetic and Plastic Surgery

摘　　要：目的　了解相对静息期增生性瘢痕、瘢痕疙瘩中凋亡特性和凋亡蛋白的表达分布。方法　利用免疫组化的方法 ,检测静息期增生性瘢痕、瘢痕疙瘩凋亡相关蛋白的表达分布和强弱。结果　发现两者的表达均处于瘢痕上皮的基底细胞层、小血管、及皮肤附件周围细胞。增生性瘢痕中 ,Bax在上述区域的表达更强 ,瘢痕疙瘩中Bax表达 ,较Bcl-2弱 ,在瘢痕疙瘩中发现 2例在瘢痕中心区的Bcl- 2弱表达。结论　静息期增生性瘢痕、瘢痕疙瘩 ,有着与增殖期不同的凋亡特性 ,凋亡上皮的基底层细胞、小血管、残存的皮肤附件周围的细胞 。Objective To study the expression and histological distributive characteristic of apoptosis related gene Bcl-2 gene and Bax gene in relative resting hypertrophic scar and keloid. Methods Utilize Immunohistochemistry to detect the expression and distributing of Bcl-2 gene and Bax gene in relative resting hypertrophic scar and keloid. Results Bcl-2 gene and Bax gene was all expression in basal layer of scar epidermis, perivascular and skin appendages cells. The positive expression of Bax gene was higher than Bcl-2 gene in above-mentioned area in hypertrophic scar , whail it lower expression than Bcl-2 gene in keloid. There were two weak expression of Bcl-2 gene in the centre of keloid. Conclusion Relative resting hypertrophic scar and keloid has a characteristic of apoptosis different from active one. The cells in basal layer of scar epidermis, perivascular and skin appendages could playinged a pivotal role during scar remodelling and apoptosis in the future.

关 键 词：基因 BCL-2 BAX 相对静息期 增生性瘢痕 瘢痕疙瘩 表达 分布 蛋白 细胞凋亡 

分 类 号：R622[医药卫生—整形外科]