左金丸和反左金对大鼠胃粘膜保护机制的比较研究  

Comparison of Protective Mechanism of Zuojin Pill and Fan Zuojin Pill on Gastric Mucosa

作　　者：陈艳芬[1] 陈蔚文[1] 李茹柳[1] 叶富强[1] 徐颂芬[1] 潘怀耿[1] 

机构地区：[1]广州中医药大学脾胃研究所,广州510405

出　　处：《广州中医药大学学报》2003年第2期133-135,共3页Journal of Guangzhou University of Traditional Chinese Medicine

基　　金：国家科技部"重大基础研究发展规划"973资助项目(编号:G19990544)

摘　　要：【目的】比较左金丸(m_(黄连):m_(吴茱萸)=6:1)和反左金(m_(黄连):m_(吴茱萸)=1:6)对胃分泌和粘液屏障的影响。【方法】采用Shay氏大鼠幽门结扎模型,大鼠分为生理盐水对照组,左金丸1.4g/kg、2.8g/kg组以及反左金1.4g/kg、2.8g/kg组,分别从十二指肠给药,观察各组大鼠的胃分泌和粘液合成的变化。【结果】1.4g/kg、2.8g/kg左金丸和反左金都能抑制胃液分泌、降低总酸排出量及胃蛋白酶活性,且随着剂量增加药效更明显;左金丸和反左金都能增加胃壁结合粘液含量,对胃液中粘液成分也有增加的趋势。【结论】左金丸和反左金可能通过影响胃分泌和粘液合成来保护胃粘膜。[ Objective] To compare the protective mechanism of Zuojin Pill (Rhizoma Coptidis: Fructus Evodiae = 6:1) and Fan Zuojin Pill (Rhizoma Coptidis: Fructus Evodiae = 1: 6) on gastric secretion and gastric mucosal barrier. [Methods] Pylorus - ligated rat model was applied. Rats were divided into normal saline group, Zuojin Pill groups (1.4 g/kg and 2.8 g/kg) and Fan Zuojin Pill groups (1.4g/kg and 2.8g/kg) and then the drugs were given by duodenal feeding. Gastric secretion and gastric mucus synthesis were examined. [Results] Zuojin Pill and Fan Zuojin Pill (1.4 g/kg and 2.8 g/kg) both inhibited gastric secretion and decreased total acid output and pepsin activity in a dose- effect manner. Zuojin Pill and Fan Zuojin Pill also increased the content of gastric adherent mucus (GAM) and tended to elevate the mucus level in gastric juice. [Conclusion] The preventive mechanism of Zuojin Pill and Fan Zuojin Pill on gastric mucosa may be related to the regulation of gastric secretion and gastric mucus synthesis.

关 键 词：左金丸 反左金 大鼠 胃粘膜损伤 保护机制 比较 药理学 生理盐水 

分 类 号：R259.73[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]