肠炎清治疗葡聚糖硫酸钠结肠炎的实验研究  

Experimental Study of Changyanqing for Colitis Induced by Dextran Sulfate Sodium

作　　者：吕永慧[1] 陈文红[2] 胡品津[2] 胡胜[2] 

机构地区：[1]广州市中医院消化内科,广州510130 [2]中山大学附属第一医院消化内科,广州510080

出　　处：《广州中医药大学学报》2003年第2期140-142,共3页Journal of Guangzhou University of Traditional Chinese Medicine

摘　　要：【目的】验证具有清热燥湿、健脾益气、理气活血作用的中药制剂肠炎清(主要由黄连、黄芪、蒲黄、白芨、元胡等中药组成)对溃疡性结肠炎的治疗效果并探讨其疗效机制。【方法】以葡聚糖硫酸钠(DSS)饮水法复制结肠炎小鼠模型,观察该药对结肠炎小鼠疾病活动指数(DAI)和肠组织髓过氧化物酶(MRO)活性的影响。【结果】肠炎清可降低DAI和MPO活性,与柳氮磺胺吡啶(SASP)疗效相当。【结论】肠炎清对DSS结肠炎有较好的治疗效果,降低MPO的活性可能是其疗效机制之一。[Objective] To observe the effects of Changyanqing, a Chinese prescription with the actions of regulating qi and activating blood, strengthening spleen-qi and clearing away heat, on ulcerative colitis (UC) and to explore its therapeutic mechanism . [ Methods ] Forty mice were randomized into Changyanqing group ( Group A ), salicylazosulfapyridine group (Group B), Changyanqing and salicylazosulfapyridine (Group C) and model group (Group D). Mouse models with UC were induced by dextran sulfate sodium (DSS). Effects of Changyanqing on disease activity index (DAI) and intestinal myeloperoxidase (MPO) content were observed. [Results] Changyanqing reduced DAI and MPO activity and its effect was similar to that of salicylazosulfapyridine. [ Conclusion ] Changyanqing exerts a better effect in treating DSS-induced UC and one of its therapeutic mechanisms may be related to the reduction of MPO activity.

关 键 词：肠炎清 中医药治疗 葡聚糖硫酸钠 结肠炎 实验 小鼠 

分 类 号：R259.746.2[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]