血清低密度脂蛋白胆固醇直接测定与公式计算结果相关性的研究  

Comparison of low-density lipoprotein cholesterol (LDL-C) measured by homogeneous assay and calculated by Friedewald formula

作　　者：刘飒[1] 刘军[1] 秦兰萍[1] 刘静[1] 蒋朝晖[2] 范荣坦[2] 

机构地区：[1]北京市心肺血管疾病研究所北京安贞医院流行病研究室,100029 [2]北京安贞医院检验科

出　　处：《心肺血管病杂志》2003年第1期1-4,共4页Journal of Cardiovascular and Pulmonary Diseases

基　　金：北京市心血管病高技术实验室课题

摘　　要：目的 :分析匀相测定法测定的血清低密度脂蛋白胆固醇 (LDL C)值与Friedewald公式 (F公式 )计算结果 ,对比二法LDL C值的差异 ,评价二种方法在大规模流行病调查和临床应用方面的适用条件及影响LDL C值的因素。方法 :对北京市自然人群采取分层随机抽样的方法进行心血管病危险因素调查 ,测定其血脂 (TC、TG、HDL C、LDL C等 )水平 ,数据完整用于分析的为 2 5～ 6 4岁的男女共计 12 18人。结果 :1 TG≤ 4 5 2mmol L时F公式法与匀相测定法的相关性 (r=0 831)好于TG >4 5 2mmol L时 (r=0 6 2 0 )。 2 比较二种方法差值的绝对值 ,在TG >4 5 2mmol L组其差值较大 ,与其它各组差值的差异均有显著性 (P <0 0 0 1)。 3 总胆固醇 (TC)水平对LDL C结果也有影响 :TG≤ 4 5 2mmol L时 ,TC <6 2 1mmol L组二种结果的相关性好于TC≥ 6 2 1mmol L组 ;而当TG >4 5 2mmol L时 ,TC <6 2 1mmol L组二种结果的差异最大 (r=0 2 19)。结论 :Friedewald公式在TG水平≤ 4 5 2mmol L时与匀相测定法相关性较好 ,且TC <6 2 1mmol L时的相关性好于TC≥ 6 2 1mmol L时。在确保TC、TG、HDL C结果准确可靠的情况下 ,可以用Friedewald公式计算的LDLObjective:To compare LDL C value measured by Homogeneous Assay and the value calculated by Friedewald formula, and to evaluate the factors effecting the difference and the fitness to large scale epidemiological survey and clinical practice.Method:A cross sectional study was carried out in a natural population of Beijing, using stratified random sampling method . Total Cholesterol (TC) , Triglycerid(TG) , High density Lipoprotein Cholesterol (HDL C), Low density Lipoprotein Cholesterol (LDL C) were measured in 1?218 individuals aged 25～64 years.Result:(1) When TG≤4 52 mmol/L,LDL C values of Friedewald formula and Homogeneous Assay correlated well (r=0 831). (2) In the group of TG>4 52 mmol/L, the absolute value of the difference between the two methods was significantly larger than in groups of TG≤4 52 mmol/L ( P <0 001) (3) When TG≤4 52 mmol/L, the correlation in the group of TC<6 21 mmol/L was better than in the group of TC≥6 21 mmol/L. The correlation was worst when TG>4 52 mmol/L and TC<6 21 mmol/L (r=0 219).Conclusion:LDL C calculated by Friedewald formula correlated well when TG ≤4 52 mmol/L especially when TC was also lower than 6 21 mmol/L. The calculated LDL C could be used as reference on the basis of reliable TC, TG and HDL C measurement

关 键 词：血清低密度脂蛋白胆固醇 相关性 匀相测定法 F公式法 动脉粥样硬化性疾病 LDL-C 

分 类 号：R446.11[医药卫生—诊断学] R543[医药卫生—临床医学]