流动注射化学发光法测定甲氧氯普胺  

Determination of metoclopramide by flow injection chemiluminescence

作　　者：范顺利[1] 张磊[1] 吴志皓[1] 林金明[2] 

机构地区：[1]河南师范大学化学与环境科学学院 [2]中国科学院生态环境研究中心,北京100085

出　　处：《分析试验室》2003年第2期48-50,共3页Chinese Journal of Analysis Laboratory

摘　　要：在酸性条件下 ,甲醛对高锰酸钾氧化甲氧氯普胺的化学发光反应有很强的增敏作用 ,据此 ,建立了流动注射化学发光法测定甲氧氯普胺的新方法。方法的线性范围为 0 .4～ 1 0 0 μg/mL ,检出限为 0 .2 μg/mL ,对 1 0 μg/mL的甲氧氯普胺标准溶液连续 1 1次测定的相对标准偏差为 1 .8%。方法已用于药物中甲氧氯普胺含量的测定。In acid medium, formaldhyde greatly enhanced the chemiluminscence produced by the oxidation of metoclopramide with potassium permanganate. Based on this, a new flow injection chemiluminscence method for the determination of metoclopramide was proposed. The linear range for the determination of metoclopramide was 0.4～100 μg/mL with the detection limit of 0.2 μg/mL . The RSD was 1.8% for 11 measurments of 10 μg/mL metoclopramide standard solution. The method was used for the determination of metoclopramide in tablets and injections with satisfactory results.

关 键 词：流动注射 化学发光法 测定 甲氧氯普胺 MCPM 高锰酸钾 胃病 药物 

分 类 号：R975.1[医药卫生—药品] R927.2[医药卫生—药学]