水溶性高分子担载二茂铁希夫碱与DNA的作用  

Studies on the Interaction of Water-Soluble Polymer-Supported Ferrocenyl Schiff Base with DNA

作　　者：刘流[1] 张海涛[1] 王云普[1] 

机构地区：[1]西北师范大学高分子研究所

出　　处：《有机化学》2003年第6期570-573,共4页Chinese Journal of Organic Chemistry

摘　　要：利用荧光探针技术和凝胶电泳等分析方法 ,对水溶性高分子聚丙烯酸 N 乙烯基吡咯烷酮和聚甲基丙烯酸 N 乙烯基吡咯烷酮担载的二茂铁希夫碱与DNA的作用进行了初步研究 .实验结果表明 :所合成的高分子二茂铁希夫碱在同DNA作用时存在有静电作用和嵌入模式 ,由于水性基团的引入和高分子链的协同效应 ,促进了配合物同DNA的这种作用 .The interaction of DNA with ferroecnyl Schiff base supported by water-soluble polyacrylic acid-co-N-vinylpyrrolidon and polymethyacrylic acid-co-N-vinylpyrrolidone was studied by fluorescent probe techniqe and gel electrophoresis analysis. The possible interaction mechanism and binding mode were proposed. The results showed the electrostatically attraction and inlay mode existed in the interaction of the water-soluble polymer-supported ferrocenyl Schiff base with DNA. Owing to the introduction of hydrophilic groups and polymer matrix effect, the activity of the interaction of DNA with the water-soluble polymer-supported ferrocenyl Schiff base became higher than that of the ferrocenyl Schiff base itself.

关 键 词：水溶性高分子担载二茂铁希夫碱 DNA 相互作用 荧光探针技术 凝胶电泳 抗肿瘤药物 

分 类 号：O641.4[理学—物理化学]