甘氨酰组氨酰赖氨酸 (GHK)的液相合成及其酶促降解  

Synthesis and Proteolysis of Gly-L-His-L-Lys(GHK)

作　　者：彭小三[1] 陈钧辉[1] 张昕[1] 张冬梅[1] 王新昌[1] 

机构地区：[1]南京大学生物化学系医药生物技术国家重点实验室,南京210093

出　　处：《中国生物化学与分子生物学报》2003年第3期406-409,共4页Chinese Journal of Biochemistry and Molecular Biology

摘　　要：Gly\| L His L Lys(GHK) was synthesized by liquid\|phase method. The HPLC analysis indicated that the proteolysis of GHK was initiated at the N terminal in liver homogenate. The result suggested that GHK was rapidly degraded by aminopeptidases in liver.Gly\| L His L Lys(GHK) was synthesized by liquid\|phase method. The HPLC analysis indicated that the proteolysis of GHK was initiated at the N terminal in liver homogenate. The result suggested that GHK was rapidly degraded by aminopeptidases in liver.

关 键 词：甘氨酰组氨酰赖氨酸 GHK 液相合成 酶促降解 肝细胞生长因子 

分 类 号：Q51[生物学—生物化学]