1-(2-羟基-5-甲基苯基)苯乙胺的合成  

Synthesis of 1-(2-hydroxy-5-methylphenyl) Phenethylamine

作　　者：吴加胜[1] 张妍[1] 张广友[1] 

机构地区：[1]济南大学化学化工学院,山东济南250022

出　　处：《济南大学学报（自然科学版）》2003年第2期107-109,共3页Journal of University of Jinan(Science and Technology)

基　　金：山东省自然科学基金资助项目 (编号Y2 0 0 2B0 5 )

摘　　要：对甲基苯酚与苯乙酰氯酯化得到苯乙酸 (4 甲基 )苯酯 ;然后在三氯化铝使用下重排得到苄基 (2 羟基 5 甲基 )苯基酮 ;此酮经硫酸二甲酯甲基化得到苄基 (2 甲氧基 5 甲基 )苯基酮 ,再和甲酸铵反应得到 1 (2 甲氧基 5 甲基苯基 )苯乙胺 ,最后经氢溴酸水解得到 1 (2 羟基 5 甲基苯基 )苯乙胺。所有中间体和最终产品的结构由红外 (IR)分析、元素分析、核磁共振 (1 HNMR)In this paper,p tolyl phenylacetate was prepared from the reaction of 4 methyphenol and phenylacetyl chloride.2 hydroxy 5 methylphenyl benzyl actone was obstained through a rearrangement reaction using AlCl 3 as catalyst.Then hydroxy was methylated by Me 2SO 4 under PTC conditions.Then 2 methoxy 5 methylphenyl benzyl actone was aminated by HCO 2NH 4,and 1 (2 methoxy 5 methylphenyl)phenethylamine was obstained.At last 1 (2 hydroxy 5 methylphenyl)phenethylamine was obstained by hydrosis reaction using hydrobromide.The structures of intermediate were confirmed by IR?element analysis and 1HNMR spectra.

关 键 词：对甲酚 苯乙酰氯 1-(2-羟基-5-甲基苯基)苯乙胺 

分 类 号：TQ226.34[化学工程—有机化工]