心力衰竭患者血浆纤溶酶原激活物抑制物-1与血管紧张素Ⅱ相关性的研究  

The relationship between plasma plasminogen activator inhibitor-1 and angiotensin Ⅱ in patients with congestive heart failure

作　　者：陈世德[1] 陶新智[1] 伍伟锋[1] 

机构地区：[1]广西医科大学心血管病研究所,南宁530021

出　　处：《临床心血管病杂志》2003年第6期336-337,341,共3页Journal of Clinical Cardiology

摘　　要：目的 :研究心力衰竭 (HF)患者血浆纤溶酶原激活物抑制物 1(PAI 1)和血管紧张素Ⅱ (AngⅡ )的变化 ,并探讨两者之间的关系。方法 :分别采用酶联免疫吸附法和放射免疫法测定 6 0例HF患者 (HF组 )及 2 0例健康人 (正常对照组 )血浆PAI 1抗原、AngⅡ水平。结果 :HF组血浆PAI 1抗原、AngⅡ水平比正常对照组明显增高 ,并且与心功能状态有关。血浆PAI 1抗原含量与AngⅡ水平呈正相关 (r =0 .994 ,P <0 .0 1)。结论 :AngⅡ是PAI 1合成与释放的重要调节者之一 ,二者相互影响可加速心功能的恶化。Objective:The aim of this study is to investigate the changes of plasma plasminogen activator inhibitor-1(PAI-1) and angiotensin II(AngII) in patients with heart failure(HF),and to explore the relationship between PAI-1 and AngII.Methods:The levels of plasma PAI-1 and AngⅡ were measured in 60 patients with HF and in 20 normal controls by enzyme-linked immunosorbent assay(ELISA) and radio immunoassay(RIA),respectively.Results:Compared with the healthy subjects, the levels of plasma PAI-1 and AngII in patients with HF were significantly increased and related to the cardiac function. There was a positive correlation between the level of plasma PAI-1 and AngII in patients with HF(r= 0.994,P< 0.01).Conclusions:Angiotensin Ⅱ is an important regulator in the synthesis and release of PAI-1. The interaction of them can deteriorate the cardiac function of patients with HF.

关 键 词：心力衰竭 纤溶酶原激活物抑制物-1 血管紧张素Ⅱ 

分 类 号：R541.6[医药卫生—心血管疾病]