硫氮酮治疗阵发性心房颤动的长期临床观察  

The long-term effect of diltiazem on paroxysmal atrial fibrillation

作　　者：刘增长[1] 殷跃辉[1] 佘强[1] 兰先彬[1] 杨晓渝[1] 罗开良[1] 

机构地区：[1]重庆医科大学附属第二医院心内科,重庆400010

出　　处：《临床心血管病杂志》2003年第6期354-355,共2页Journal of Clinical Cardiology

摘　　要：目的 :探讨硫氮酮对阵发性心房颤动 (房颤 )的治疗效果。方法 :选择 6 2例阵发性房颤患者 ,随机分为硫氮酮组 (31例 )和对照组 (31例 ) ,随访 3年 ,观察房颤年发作次数、持续时间和转变为持续性房颤的情况。结果 :①硫氮酮明显减少房颤年发作次数、持续时间 (P <0 .0 1) ,但用药后 1～ 2年间差异无显著性意义(P >0 .0 5 ) ;②对照组房颤年发作次数、持续时间逐年增加 ,年与年之间差异有非常显著性意义 (P <0 .0 1) ;③随访期间 ,对照组有 6例而硫氮酮组无一例转变为持续性房颤 ,两组间差异有显著性意义 (P <0 .0 5 )。结论 :硫氮酮可明显减少阵发性房颤发作次数和持续时间 ,在阻止其转变为持续性房颤也有一定的作用 。Objective:To investigate the effect of diltiazem on paroxysmal atrial fibrillation.Methods:Sixty-two patients with paroxysmal atrial fibrillation(PAF) were randomly divided into diltiazem group(31 patients) and control group(31 patients). During follow-up 3 year, the epieode of annual frequency 、duration and changing to persistent atrial fibrillation of PAF were recorded.Results:①Diltiazem could significantly reduced the episode to annual frequency and duration of PAF(P< 0.01),but there was no significant difference during the first and second year after oral diltiazem(P> 0.05). ②The episode of annual frequency and duration of atrial fibrillation in control group increased,and the annual differences were significant(P< 0.01). ③Six patients in control group and 0 patient in diltiazem group becomed persistent AF patients (P< 0.05).Conclusion:Diltiazem significantly reduce the frequency and duration of PAF,and it can play a role in preventing PAF to become persistent atrial fibrillation.It is presumed that Diltiazem can prevent atrial electrical remodeling.

关 键 词：心房颤动 硫氮ZHUO酮 

分 类 号：R541.7[医药卫生—心血管疾病] R972[医药卫生—内科学]