枸杞多糖的抗肿瘤活性和对免疫功能的影响  

EFFECT OF LYCIUM BARBARUM POLYSACCHARIDE ON ANTITUMOR ACTIVITY AND IMMUNE FUNCTION

作　　者：甘璐[1] 张声华[2] 

机构地区：[1]华中科技大学化学系药物研究所,武汉430074 [2]华中农业大学食品科技系,武汉430070

出　　处：《营养学报》2003年第2期200-202,214,共4页Acta Nutrimenta Sinica

基　　金：湖北省自然科学基金 ( N o.95J2 5)

摘　　要：目的 :　研究枸杞多糖 LBP-X的抗肿瘤效果及对荷瘤鼠免疫功能的调节作用。方法 :　采用小鼠 S1 80 实体瘤模型观察 LBP-X的体内抑瘤作用 ,并进行了免疫学指标测定。结果 :　LBP-X具有明显的抗肿瘤活性 ,且可显著提高荷瘤鼠胸腺指数、巨噬细胞吞噬功能、脾细胞抗体形成、淋巴细胞转化反应、细胞毒性 T淋巴细胞杀伤功能及降低脂质过氧化值。结论 :　Objective: To study the antitumor effect of Lycium barbarum polysaccharide (LBP X) and its immunity regulating effect on S 180 bearing mice. Methods: S 180 bearing mice were used as animal model. The effect of LBP X on tumor weight and immune function was observed. Results: LBP X could inhibit the growth of S 180 effectively and increase thymus index, the macrophage phagocytic function, anti SRBC antibody secreted by the spleen cells, lymphocyte proliferation and CTL activity and decrease LPO markedly in S 180 bearing mice. Conclusion: The mechanism of tumor inhibition by LBP X was due to enhance the immune function.

关 键 词：枸杞多糖 肿瘤 免疫功能 动物实验 

分 类 号：R285[医药卫生—中药学]